ArticlePLoS pathogens2013
Serotonergic chemosensory neurons modify the C. elegans immune response by regulating G-protein signaling in epithelial cells.
Article in PLoS pathogens, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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Who cites it
32 citing papers in PubMed, 57 citations in OpenAlex.
- Neural regulation of infection resolution prevents ER stress and tissue damage.bioRxiv : the preprint server for biology · 2026Article
- NMDA Receptor Subunit NMR-2 Regulates Pathogen-Induced Immune Responses via the Nervous System inbioRxiv : the preprint server for biology · 2026Article
- Worming out defence strategies: mechanisms of immunity through the lens of genetic screens in C. elegans.Heredity · 2026Review
- Neurotransmitter signaling in molecular and behavioral immune responses to pathogens inMicrobiology and molecular biology reviews : MMBR · 2025Review
- Neuroimmune Circuits in Allergic Diseases.Annual review of immunology · 2025Review
- Serotonin deficiency from constitutive SKN-1 activation drives pathogen apathy.Nature communications · 2024Article
- Dissecting the genetic landscape of GPCR signaling through phenotypic profiling in C. elegans.Nature communications · 2023Article
- Moderate intensity of static magnetic fields can alter the avoidance behavior and fat storage of Caenorhabditis elegans via serotonin.Environmental science and pollution research international · 2022Article
- Nuclear translocation of the tagged endogenous MAPK MPK-1 denotes a subset of activation events in C. elegans development.Journal of cell science · 2021Article
- Immunity-longevity tradeoff neurally controlled by GABAergic transcription factor PITX1/UNC-30.Cell reports · 2021Article
- Detection of Pathogens and Regulation of Immunity by the Caenorhabditis elegans Nervous System.mBio · 2021Review
- Complement Has Brains-Do Intracellular Complement and Immunometabolism Cooperate in Tissue Homeostasis and Behavior?Frontiers in immunology · 2021Review
- Neuro-immune communication inCurrent research in immunology · 2021Article
- G protein-coupled receptors: The choreographers of innate immunity in Caenorhabditis elegans.PLoS pathogens · 2021Review
- A trade-off switch of two immunological memories inThe Journal of biological chemistry · 2020Article
- MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity.Nature communications · 2020Article
- Receptors Mediating Host-Microbiota Communication in the Metaorganism: The Invertebrate Perspective.Frontiers in immunology · 2020Review
- The Role of Neurotransmitters in the Protection ofFrontiers in cellular and infection microbiology · 2020Article
- Neuronal GPCR NPR-8 regulatesScience advances · 2019Article
- Role of neurons in the control of immune defense.Current opinion in immunology · 2019Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The nervous and immune systems influence each other, allowing animals to rapidly protect themselves from changes in their internal and external environment. However, the complex nature of these systems in mammals makes it difficult to determine how neuronal signaling influences the immune response. Here we show that serotonin, synthesized in Caenorhabditis elegans chemosensory neurons, modulates the immune response. Serotonin released from these cells acts, directly or indirectly, to regulate G-protein signaling in epithelial cells. Signaling in these cells is required for the immune response to infection by the natural pathogen Microbacterium nematophilum. Here we show that serotonin signaling suppresses the innate immune response and limits the rate of pathogen clearance. We show that C. elegans uses classical neurotransmitters to alter the immune response. Serotonin released from sensory neurons may function to modify the immune system in response to changes in the animal's external environment such as the availability, or quality, of food.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.