ReviewTheScientificWorldJournal2013
Pharmacological effects of active compounds on neurodegenerative disease with gastrodia and uncaria decoction, a commonly used poststroke decoction.
Review in TheScientificWorldJournal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Pharmacological Mechanisms of Phytochemicals and Pharmaceutical Agents in Protecting Against Methotrexate-Induced Liver Injury.Oxidative medicine and cellular longevity · 2026Review
- Compounds from medicinal plants produced in hairy root and transgenic hairy root cultures: a review.PeerJ · 2025Review
- Geographical variation in metabolite profiles and bioactivity ofFrontiers in plant science · 2024Article
- Phytochemical analysis and biological investigation ofFrontiers in pharmacology · 2024Article
- Therapeutic Potential of the GenusSouth African journal of botany : official journal of the South African Association of Botanists = Suid-Afrikaanse tydskrif vir plantkunde : amptelike tydskrif van die Suid-Afrikaanse Genootskap van Plantkundiges · 2023Article
- A Comprehensive Review onPlants (Basel, Switzerland) · 2023Review
- Alkaloids Used as Medicines: Structural Phytochemistry Meets Biodiversity-An Update and Forward Look.Molecules (Basel, Switzerland) · 2021Review
- Early intervention combining Chinese and Western medicine in traumatic brain injury with diffuse axonal injury: A report of three cases.Journal of traditional and complementary medicine · 2020Article
- Pharmacokinetic and Lipidomic Assessment of the In Vivo Effects of Parishin A-Isorhynchophylline in Rat Migraine Models.Journal of analytical methods in chemistry · 2020Article
- In vitro and in vivo evaluation of the neuroprotective activity of Uncaria hirsuta Haviland.Journal of food and drug analysis · 2020Article
- Structure Characterization and Action Mechanism of an Antiaging New Compound fromOxidative medicine and cellular longevity · 2019Article
- Long-term survival in a patient with pulmonary spindle cell carcinoma treated with traditional Chinese medicine.BMJ case reports · 2018Article
- A Computational Systems Pharmacology Approach to Investigate Molecular Mechanisms of Herbal Formula Tian-Ma-Gou-Teng-Yin for Treatment of Alzheimer's Disease.Frontiers in pharmacology · 2018Article
- Inhibitory effect ofNutrition research and practice · 2017Article
- Association of traditional Chinese medicine therapy and the risk of dementia in patients with hypertension: a nationwide population-based cohort study.BMC complementary and alternative medicine · 2017Article
- Article
- Patterns of Chinese medicine use in prescriptions for treating Alzheimer's disease in Taiwan.Chinese medicine · 2016Article
- Tianma Gouteng Yin, a Traditional Chinese Medicine decoction, exerts neuroprotective effects in animal and cellular models of Parkinson's disease.Scientific reports · 2015Article
- Neuropharmacological Potential of Gastrodia elata Blume and Its Components.Evidence-based complementary and alternative medicine : eCAM · 2015Review
- Herbal medicines and kidney; friends or foes?Journal of nephropharmacology · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurodegenerative diseases refer to the selective loss of neuronal systems in patients. The diseases cause high morbidity and mortality to approximately 22 million people worldwide and the number is expected to be tripled by 2050. Up to now, there is no effective prevention and treatment for the neurodegenerative diseases. Although some of the clinical therapies target at slowing down the progression of symptoms of the diseases, the general effectiveness of the drugs has been far from satisfactory. Traditional Chinese medicine becomes popular alternative remedies as it has been practiced clinically for more than thousands of years in China. As neurodegenerative diseases are mediated through different pathways, herbal decoction with multiple herbs is used as an effective therapeutic approach to work on multiple targets. Gastrodia and Uncaria Decoction, a popular TCM decoction, has been used to treat stroke in China. The decoction contains compounds including alkaloids, flavonoids, iridoids, carotenoids, and natural phenols, which have been found to possess anti-inflammatory, antioxidative, and antiapoptotic effects. In this review, we will summarize the recent publications of the pharmacological effects of these five groups of compounds. Understanding the mechanisms of action of these compounds may provide new treatment opportunities for the patients with neurodegenerative diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.