Evidence map›Paper›PMID 24348030›Full record

ArticleInternational journal of chronic obstructive pulmonary disease2013

Over diagnosis of chronic obstructive pulmonary disease in an underserved patient population.

Christian Ghattas, Allen Dai, David J Gemmel, Magdi H Awad

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in International journal of chronic obstructive pulmonary disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03137303 (Reducing Diagnostic Error to Improve Patient Safety in COPD and Asthma), which is not on this map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03137303 phase3completednot on this mapstarted 2017, after this paper: background citation

Reducing Diagnostic Error to Improve Patient Safety in COPD and Asthma (REDEFINE Study)

TypeinterventionalSponsorUniversity of Illinois at ChicagoRan2017 to 2019Enrolled402ConditionsCOPD AsthmaArmsSpirometry at initial visit, Albuterol, Spirometry at 12-month follow-up
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Lung Cancer Risk in US Adults with COPD: A Systematic Review and Meta-Analysis.International journal of chronic obstructive pulmonary disease · 2025
    Pooled it
  2. Pooled it
  3. The effect of a post-bronchodilator FEVRespiratory research · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Inhaled therapies in patients with moderate COPD in clinical practice: current thinking.International journal of chronic obstructive pulmonary disease · 2018
    Review
  10. Quality of Chronic Obstructive Pulmonary Disease-Related Health Care in Rural and Urban Veterans Affairs Clinics.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2017
    Article
  11. Overdiagnosis of COPD in hospitalized patients.International journal of chronic obstructive pulmonary disease · 2017
    Article
  12. Action plans for COPD: strategies to manage exacerbations and improve outcomes.International journal of chronic obstructive pulmonary disease · 2016
    Review
  13. The concept of control of COPD in clinical practice.International journal of chronic obstructive pulmonary disease · 2014
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Christian GhattasDepartment of Internal Medicine, St Elizabeth Health Center, Youngstown, OH, USA.
Allen DaiNortheast Ohio Medical University College of Pharmacy, Rootstown, OH, USA.
David J GemmelDepartment of Medical Education and Research, St Elizabeth Health Center, Youngstown, OH, USA.
Magdi H AwadNortheast Ohio Medical University College of Pharmacy, Rootstown, OH, USA.
Northeast Ohio Medical University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWhile cross-national studies have documented rates of chronic obstructive pulmonary disease (COPD) misdiagnosis among patients in primary care, US studies are scarce. Studies investigating diagnosis among uninsured patients are lacking.

objectiveThe purpose of this study is to identify patients who are over diagnosed and thus, mistreated, for COPD in a federally qualified health center.

methodsA descriptive study was conducted for a retrospective cohort from February 2011 to June 2012. Spirometry was performed by trained personnel following American Thoracic Society recommendations. Patients were referred for spirometry to confirm previous COPD diagnosis or to assess uncontrolled COPD symptoms. Airway obstruction was defined as a forced expiratory volume in the first second of expiration (FEV1) to forced vital capacity ratio less than 0.7. Reversibility was defined as a postbronchodilator increase in FEV1 greater than 200 mL and greater than 12%.

resultsEighty patients treated for a previous diagnosis of COPD (n = 72) or on anticholinergic inhalers (n = 8) with no COPD diagnosis were evaluated. The average age was 52.9 years; 71% were uninsured. Only 17.5% (14/80) of patients reported previous spirometry. Spirometry revealed that 42.5% had no obstruction, 22.5% had reversible obstruction, and 35% had non-reversible obstruction.

conclusionSymptoms and smoking history are insufficient to diagnose COPD. Prevalence of COPD over diagnosis among uninsured patient populations may be higher than previously reported. Confirming previous COPD diagnosis with spirometry is essential to avoid unnecessary and potentially harmful treatment.

Indexed as

Diagnostic ErrorsMedically Underserved AreaSpirometryVulnerable PopulationsAdministration, InhalationAdultBronchodilator AgentsCholinergic AntagonistsFemaleForced Expiratory VolumeHumansLungMaleMedically UninsuredMiddle AgedOhioBronchodilator AgentsCholinergic Antagonistschronic obstructive pulmonary diseaseCOPDmisdiagnosisover diagnosisspirometryunderserveduninsured

Identifiers

PMID24348030
PMCPMC3848507
OpenAlexW2036586850

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.