ArticleJournal of neurosciences in rural practice2013
Depression and sleep disturbances in patients with multiple sclerosis and correlation with associated fatigue.
Article in Journal of neurosciences in rural practice, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Pooled it
- Neuropsychiatric symptoms and their impact on quality of life among patients with multiple sclerosis.Indian journal of psychiatry · 2026Article
- Fatigue, Insomnia, and Disability as Independent Predictors of Depressive Symptoms in Multiple Sclerosis: A Prospective Observational Study.Sisli Etfal Hastanesi tip bulteni · 2025Article
- A multidimensional approach to sleep health in multiple sclerosis.Multiple sclerosis and related disorders · 2021Article
- Relationship between Fatigue and Physical Activity in a Polish Cohort of Multiple Sclerosis Patients.Medicina (Kaunas, Lithuania) · 2020Article
- Fatigue after a first attack of suspected multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2018Article
- Factors Associated with Poor Sleep in Older Adults with Multiple Sclerosis.International journal of behavioral medicine · 2017Article
- Focal Injection of Ethidium Bromide as a Simple Model to Study Cognitive Deficit and Its Improvement.Basic and clinical neuroscience · 2016Article
- Aspirin and multiple sclerosis.BMC medicine · 2015Review
- Multiple Sclerosis in India.Annals of Indian Academy of NeurologyArticle
- The Effect of Group Cognitive Behavioral Therapy on Stress, Anxiety, and Depression of Women with Multiple Sclerosis.Iranian journal of nursing and midwifery researchArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo observe prevalence of depression and sleep disturbances in multiple sclerosis (MS) patients and their correlation with associated fatigue. STUDY DESIGN AND
settingProspective observation study in a university tertiary research hospital in India. MATERIALS AND
methodsThirty-one patients (6 male and 25 female) with definite MS (McDonald's criteria) presented in out-patient/admitted in the department of neurology (between February 2010 and December 2011) were included in the study. Depression was assessed using Beck's Depression Inventory (BDI). Sleep quality was assessed using Pittsburg Sleep Quality Index (PSQI). Disease severity was evaluated using the Kurtzke's expanded disability status scale (EDSS). Fatigue was assessed using Krupp's fatigue severity scale (FSS). We tried to observe correlation of depression and sleep disturbance with associated fatigue in MS patients.
resultsThe age of patients varied between 16 and 50 years (30.1 ± 9.1). The mean age at first symptom was 25.2 ± 6.4 years (range 14-39 years). The prevalence of sleep disturbance and depression was 51.6% (16/31) each and fatigue 58.1% (18/31) in the study group. The PSQI scores were significantly greater in the patients with fatigue as compared with those without fatigue indicating poorer sleep quality is associated with fatigue in MS (P = 0.005). The BDI scores were also significantly higher in the fatigue group showing that severity of depression also strongly correlated with fatigue (P = 0.001).
conclusionsDepression and sleep disturbance in patients with MS is significantly correlated with associated fatigue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.