Evidence map›Paper›PMID 24347799›Full record

ArticleDisease markers2013

Risk factors for mortality in hemodialysis patients: two-year follow-up study.

Maria do Sameiro-Faria, Sandra Ribeiro, Elísio Costa, Denisa Mendonça, Laetitia Teixeira, Petronila Rocha-Pereira, João Fernandes, Henrique Nascimento, Michaela Kohlova, Flávio Reis and 6 more

Registry-linked trialAbstract read
In one paragraph

Article in Disease markers, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05028595 (Evaluation of Hepatic Affection in Hemodialysis Patients With Iron Overload in Assiut University Hospital), which is not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05028595 completednot on this mapstarted 2019, after this paper: background citation

Evaluation of Hepatic Affection in Hemodialysis Patients With Iron Overload in Assiut University Hospital

TypeobservationalSponsorAssiut UniversityRan2019 to 2020Enrolled80ConditionsHepatic Injury
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Observational
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Observational
  13. Article
  14. Article
  15. Article
  16. Neutrophil Elastase Inhibitors and Chronic Kidney Disease.International journal of biological sciences · 2018
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Maria do Sameiro-FariaInstituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal ; Nephrocare Portugal, SA-Nephrocare Maia, Maia, Portugal.
Sandra RibeiroLaboratório de Bioquímica, Departamento de Ciências Biológicas, Faculdade Farmácia, Universidade do Porto, Porto, Portugal ; Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal.
Elísio CostaLaboratório de Bioquímica, Departamento de Ciências Biológicas, Faculdade Farmácia, Universidade do Porto, Porto, Portugal ; Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal.
Denisa MendonçaInstituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal ; Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.
Laetitia TeixeiraInstituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal.
Petronila Rocha-PereiraInstituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal ; Centro Investigação Ciências Saúde, Universidade Beira Interior, Covilhã, Portugal.
João FernandesInstituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal ; IBILI, Faculdade de Medicina, Universidade de Coimbra, Coimbra, Portugal.
Henrique NascimentoLaboratório de Bioquímica, Departamento de Ciências Biológicas, Faculdade Farmácia, Universidade do Porto, Porto, Portugal ; Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal.
Michaela KohlovaCentro Investigação Ciências Saúde, Universidade Beira Interior, Covilhã, Portugal.
Flávio ReisCentro Investigação Ciências Saúde, Universidade Beira Interior, Covilhã, Portugal.
Leonilde AmadoNephrocare Portugal, SA-Nephrocare Maia, Maia, Portugal.
Elsa Bronze-da-RochaLaboratório de Bioquímica, Departamento de Ciências Biológicas, Faculdade Farmácia, Universidade do Porto, Porto, Portugal ; Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal.
Vasco MirandaNephrocare Portugal, SA-Nephrocare Maia, Maia, Portugal.
Alexandre QuintanilhaInstituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal ; Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal.
Luís BeloLaboratório de Bioquímica, Departamento de Ciências Biológicas, Faculdade Farmácia, Universidade do Porto, Porto, Portugal ; Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal.
Alice Santos-SilvaLaboratório de Bioquímica, Departamento de Ciências Biológicas, Faculdade Farmácia, Universidade do Porto, Porto, Portugal ; Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal ; Serviço de Bioquímica, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Rua Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEnd-stage renal disease (ESRD) patients under hemodialysis (HD) have high mortality rate. Inflammation, dyslipidemia, disturbances in erythropoiesis, iron metabolism, endothelial function, and nutritional status have been reported in these patients. Our aim was to identify any significant association of death with these disturbances, by performing a two-year follow-up study. METHODS AND

resultsA large set of data was obtained from 189 HD patients (55.0% male; 66.4 ± 13.9 years old), including hematological data, lipid profile, iron metabolism, nutritional, inflammatory, and endothelial (dys)function markers, and dialysis adequacy.

results35 patients (18.5%) died along the follow-up period. Our data showed that the type of vascular access, C-reactive protein (CRP), and triglycerides (TG) are significant predictors of death. The risk of death was higher in patients using central venous catheter (CVC) (Hazard ratio [HR] = 3.03, 95% CI = 1.49-6.13), with higher CRP levels (fourth quartile), compared with those with lower levels (first quartile) (HR = 17.3, 95% CI = 2.40-124.9). Patients with higher TG levels (fourth quartile) presented a lower risk of death, compared with those with the lower TG levels (first quartile) (HR = 0.18, 95% CI = 0.05-0.58).

conclusionsThe use of CVC, high CRP, and low TG values seem to be independent risk factors for mortality in HD patients.

Indexed as

Renal DialysisAdultAgedAged, 80 and overC-Reactive ProteinFemaleFollow-Up StudiesHumansKidney Failure, ChronicMaleMiddle AgedProportional Hazards ModelsRisk FactorsTreatment OutcomeTriglyceridesC-Reactive ProteinTriglycerides

Identifiers

PMID24347799
PMCPMC3857718

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.