ArticleG3 (Bethesda, Md.)2014
Multigenic natural variation underlies Caenorhabditis elegans olfactory preference for the bacterial pathogen Serratia marcescens.
Article in G3 (Bethesda, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Wild strains reveal natural variation in C. elegans avoidance behaviors.G3 (Bethesda, Md.) · 2025Article
- Host avoidance and resistance vary independently and are specific to parasite genotype.The Journal of animal ecology · 2025Article
- Identification of bacterial signals that modulate enteric sensory neurons to influence behavior inbioRxiv : the preprint server for biology · 2025Article
- Life history in Caenorhabditis elegans: from molecular genetics to evolutionary ecology.Genetics · 2024Review
- Making "Sense" of Ecology from a Genetic Perspective:Metabolites · 2022Review
- Wild-type Caenorhabditis elegans isolates exhibit distinct gene expression profiles in response to microbial infection.BMC genomics · 2022Article
- The Role of Serratomolide-like Amino Lipids Produced by Bacteria of GenusPathogens (Basel, Switzerland) · 2022Article
- Review
- An automated approach to quantify chemotaxis index inmicroPublication biology · 2022Article
- Article
- From QTL to gene: C. elegans facilitates discoveries of the genetic mechanisms underlying natural variation.Trends in genetics : TIG · 2021Review
- Trimethylamine modulates dauer formation, neurodegeneration, and lifespan through tyra-3/daf-11 signaling in Caenorhabditis elegans.Aging cell · 2021Article
- These Are the Genes You're Looking For: Finding Host Resistance Genes.Trends in microbiology · 2021Review
- Interpopulational Variations of Odorant-Binding Protein Expression in the Black Cutworm Moth,Insects · 2020Article
- Natural variation in the sequestosome-related gene, sqst-5, underlies zinc homeostasis in Caenorhabditis elegans.PLoS genetics · 2020Article
- The GeneG3 (Bethesda, Md.) · 2020Article
- The AncestralG3 (Bethesda, Md.) · 2020Article
- Genetic Variation inMicroorganisms · 2020Review
- Host heterogeneity mitigates virulence evolution.Biology letters · 2020Article
- WormQTL2: an interactive platform for systems genetics in Caenorhabditis elegans.Database : the journal of biological databases and curation · 2020Article
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3 authors.
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Abstract
The nematode Caenorhabditis elegans can use olfaction to discriminate among different kinds of bacteria, its major food source. We asked how natural genetic variation contributes to choice behavior, focusing on differences in olfactory preference behavior between two wild-type C. elegans strains. The laboratory strain N2 strongly prefers the odor of Serratia marcescens, a soil bacterium that is pathogenic to C. elegans, to the odor of Escherichia coli, a commonly used laboratory food source. The divergent Hawaiian strain CB4856 has a weaker attraction to Serratia than the N2 strain, and this behavioral difference has a complex genetic basis. At least three quantitative trait loci (QTLs) from the CB4856 Hawaii strain (HW) with large effect sizes lead to reduced Serratia preference when introgressed into an N2 genetic background. These loci interact and have epistatic interactions with at least two antagonistic QTLs from HW that increase Serratia preference. The complex genetic architecture of this C. elegans trait is reminiscent of the architecture of mammalian metabolic and behavioral traits.
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