ArticleG3 (Bethesda, Md.)2014
Heterosis is prevalent among domesticated but not wild strains of Saccharomyces cerevisiae.
Article in G3 (Bethesda, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 53 citations in OpenAlex.
- Influence of Ploidy and Genetic Background on Stress Tolerance of Intraspecific Yeast Hybrids.Microbial biotechnology · 2026Article
- Graph-Based Pan-Genome Reveals the Pattern of Deleterious Mutations during the Domestication ofJournal of fungi (Basel, Switzerland) · 2024Article
- High quality de novo genome assembly of the non-conventional yeast Kazachstania bulderi describes a potential low pH production host for biorefineries.Communications biology · 2023Article
- Genome-scale patterns in the loss of heterozygosity incidence in Saccharomyces cerevisiae.Genetics · 2022Article
- The Ecology and Evolution of the Baker's YeastGenes · 2022Review
- Improved redox homeostasis owing to the up-regulation of one-carbon metabolism and related pathways is crucial for yeast heterosis at high temperature.Genome research · 2021Article
- Recombining Your Way Out of Trouble: The Genetic Architecture of Hybrid Fitness under Environmental Stress.Molecular biology and evolution · 2020Article
- Article
- A Case Study of Genomic Instability in an Industrial Strain ofG3 (Bethesda, Md.) · 2018Article
- The optimal mating distance resulting from heterosis and genetic incompatibility.Science advances · 2018Article
- The origin and adaptive evolution of domesticated populations of yeast from Far East Asia.Nature communications · 2018Article
- A UniqueFrontiers in microbiology · 2018Article
- New Lager Brewery Strains Obtained by Crossing Techniques UsingApplied and environmental microbiology · 2017Article
- Heterosis as a consequence of regulatory incompatibility.BMC biology · 2017Article
- Power provides protection: Genetic robustness in yeast depends on the capacity to generate energy.PLoS genetics · 2017Article
- Genetic Causes of Phenotypic Adaptation to the Second Fermentation of Sparkling Wines inG3 (Bethesda, Md.) · 2017Article
- Novel brewing yeast hybrids: creation and application.Applied microbiology and biotechnology · 2017Review
- Powerful decomposition of complex traits in a diploid model.Nature communications · 2016Article
- Ploidy influences the functional attributes of de novo lager yeast hybrids.Applied microbiology and biotechnology · 2016Article
- Social wasps are a Saccharomyces mating nest.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Crosses between inbred but unrelated individuals often result in an increased fitness of the progeny. This phenomenon is known as heterosis and has been reported for wild and domesticated populations of plants and animals. Analysis of heterosis is often hindered by the fact that the genetic relatedness between analyzed organisms is only approximately known. We studied a collection of Saccharomyces cerevisiae isolates from wild and human-created habitats whose genomes were sequenced and thus their relatedness was fully known. We reasoned that if these strains accumulated different deleterious mutations at an approximately constant rate, then heterosis should be most visible in F1 heterozygotes from the least related parents. We found that heterosis was substantial and positively correlated with sequence divergence, but only in domesticated strains. More than 80% of the heterozygous hybrids were more fit than expected from the mean of their homozygous parents, and approximately three-quarters of those exceeded even the fittest parent. Our results support the notion that domestication brings about relaxation of selection and accumulation of deleterious mutations. However, other factors may have contributed as well. In particular, the observed build-up of genetic load might be facilitated by a decrease, and not increase, in the rate of inbreeding.
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