ArticlePhytotherapy research : PTR2014
Pentalinon andrieuxii root extract is effective in the topical treatment of cutaneous leishmaniasis caused by Leishmania mexicana.
Article in Phytotherapy research : PTR, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Pentalinonsterol at the Host-Parasite Interface: Antileishmanial Activity, Host Immunomodulation, and Unresolved Mechanisms.Acta parasitologica · 2026Review
- Identifying immunostimulatory herbal supplements that may flare autoimmune skin diseases: a systematic scoping review.Lupus science & medicine · 2025Article
- Exploration of Antileishmanial Compounds Derived from Natural Sources.Anti-inflammatory & anti-allergy agents in medicinal chemistry · 2024Review
- In vitro leishmanicidal activity of two cholesterol derivatives.World journal of microbiology & biotechnology · 2022Article
- Pentalinonsterol, a Phytosterol from Pentalinon andrieuxii, is Immunomodulatory through Phospholipase ACell biochemistry and biophysics · 2022Article
- The Potential of Traditional Knowledge to Develop Effective Medicines for the Treatment of Leishmaniasis.Frontiers in pharmacology · 2021Review
- Nanoparticulate drug delivery systems for the treatment of neglected tropical protozoan diseases.The journal of venomous animals and toxins including tropical diseases · 2019Article
- Decanethiol functionalized silver nanoparticles are new powerful leishmanicidals in vitro.World journal of microbiology & biotechnology · 2018Article
- Pentalinonsterol, a Constituent of Pentalinon andrieuxii, Possesses Potent Immunomodulatory Activity and Primes T Cell Immune Responses.Journal of natural products · 2017Article
- A New Antileishmanial Preparation of Combined Solamargine and Solasonine Heals Cutaneous Leishmaniasis through Different Immunochemical Pathways.Antimicrobial agents and chemotherapy · 2016Article
- A Novel Sterol Isolated from a Plant Used by Mayan Traditional Healers Is Effective in Treatment of Visceral Leishmaniasis Caused by Leishmania donovani.ACS infectious diseases · 2015Article
- Uncovering Leishmania-macrophage interplay using imaging flow cytometry.Journal of immunological methods · 2015Article
- Modulation of dendritic cell immune functions by plant components.Journal of microscopy and ultrastructureReview
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
Cutaneous leishmaniasis (CL) manifests as localized skin lesions, which lead to significant tissue destruction and disfigurement. In the Yucatan Peninsula, Mayan traditional healers use Pentalinon andrieuxii Muell.-Arg. (Apocynaceae) roots for the topical treatment of CL. Here, we studied the effect of P. andrieuxii root hexane extract (PARE) on the parasites and host cells in vitro and examined its efficacy in the topical treatment of CL caused by Leishmania mexicana. PARE exhibited potent antiparasitic activity in vitro against promastigotes as well as amastigotes residing in macrophages. Electron microscopy of PARE-treated parasites revealed direct membrane damage. PARE also activated nuclear factor kappaB and enhanced interferon-γ receptor and MHC class II expression and TNF-α production in macrophages. In addition, PARE induced production of the Th1 promoting cytokine IL-12 in dendritic cells as well as enhanced expression of the co-stimulatory molecules CD40, CD80, and CD86. In vivo studies showed that L. mexicana-infected mice treated by topical application of PARE resulted in the significant reduction in lesion size and parasite burden compared to controls. These findings indicate that PARE could be used as an alternative therapy for the topical treatment of CL.
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