ArticleJournal of psychopharmacology (Oxford, England)2014
Endothelial nitric oxide synthetase genetic variants, metabolic syndrome and endothelial function in schizophrenia.
Article in Journal of psychopharmacology (Oxford, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- The impact of muscarinic and mGlu receptors modulators on MK-801-induced impairments in NO-dependent processes both in vitro and in vivo.Pharmacological reports : PR · 2025Article
- Schizophrenia endothelial cells exhibit higher permeability and altered angiogenesis patterns in patient-derived organoids.Translational psychiatry · 2024Article
- A role for endothelial NMDA receptors in the pathophysiology of schizophrenia.Schizophrenia research · 2022Review
- An Optical Coherence Tomography Study that Supports the Neurovascular Basis of Schizophrenia Disease.Alpha psychiatry · 2022Article
- From Neurodevelopmental to Neurodegenerative Disorders: The Vascular Continuum.Frontiers in aging neuroscience · 2021Review
- Endothelial dysfunction in neuroprogressive disorders-causes and suggested treatments.BMC medicine · 2020Review
- The Inflamed Brain in Schizophrenia: The Convergence of Genetic and Environmental Risk Factors That Lead to Uncontrolled Neuroinflammation.Frontiers in cellular neuroscience · 2020Review
- The Relationship between 10 Years Risk of Cardiovascular Disease and Schizophrenia Symptoms: Preliminary Results.Psychiatry investigation · 2019Article
- Metabolic syndrome is negatively associated with cognition among endothelial nitric oxide synthase (eNOS)- 786C carriers in schizophrenia-spectrum disorders.Journal of psychiatric research · 2019Article
- Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?Metabolic brain disease · 2019Review
- Haplotype analysis of endothelial nitric oxide synthase (NOS3) genetic variants and metabolic syndrome in healthy subjects and schizophrenia patients.International journal of obesity (2005) · 2018Article
- The Influence of Metabolic Syndrome and Sex on the DNA Methylome in Schizophrenia.International journal of genomics · 2018Article
- Neurovascular Unit Dysfunction and Blood-Brain Barrier Hyperpermeability Contribute to Schizophrenia Neurobiology: A Theoretical Integration of Clinical and Experimental Evidence.Frontiers in psychiatry · 2017Review
- Oxytocin ReceptorMolecular neuropsychiatry · 2016Article
- Role of Immune and Autoimmune Dysfunction in Schizophrenia.Handbook of behavioral neuroscience · 2016Article
- The Gut Microbiota and the Emergence of Autoimmunity: Relevance to Major Psychiatric Disorders.Current pharmaceutical design · 2016Review
- A Population-Based Cohort Study on Peripheral Arterial Disease in Patients with Schizophrenia.PloS one · 2016Article
- Gastroenterology issues in schizophrenia: why the gut matters.Current psychiatry reports · 2015Review
- Asymmetric dimethylarginine in somatically healthy schizophrenia patients treated with atypical antipsychotics: a case-control study.BMC psychiatry · 2015Article
- IgG dynamics of dietary antigens point to cerebrospinal fluid barrier or flow dysfunction in first-episode schizophrenia.Brain, behavior, and immunity · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe increasing rates of metabolic syndrome and cardiovascular disease in schizophrenia led to investigation into their causes, including atypical antipsychotics and pharmacogenetic variants. This study focused on the peripheral vasculature as a cardiovascular phenotype and the influence of atypical antipsychotics, the aberrant metabolism of nitric oxide caused by endothelial nitric oxide synthetase (eNOS) genetic variants and metabolic syndrome in a cross-sectional sample of schizophrenia subjects.
methodsAssociations between eNOS genetic variants and endothelial function was assessed in a cohort of schizophrenia patients taking antipsychotic drugs, whom were undergoing a clinical assessment for endothelial function via the method of peripheral artery tonometry (RH-PAT), as well as metabolic syndrome criteria screening. Analyses were conducted on the entire cohort, then again after stratifying by metabolic syndrome, to investigate the effect of the eNOS variants and metabolic syndrome on endothelial functionality.
resultsWe included 203 subjects with a mean age of 46 years. The cohort was 36% female, 36% had metabolic syndrome and 85% were currently using atypical antipsychotics. We found associations between the eNOS T⁻⁷⁸⁶C and worse endothelial functioning (lower RH-PAT values) only in schizophrenia patients without metabolic syndrome.
conclusionsOur results suggested that when schizophrenia patients progress to meet metabolic syndrome criteria, the genetic protection of the eNOS T⁻⁷⁸⁶C variant on endothelial function is no longer seen: Other factors of this pro-inflammatory state may be overriding this effect. The results of this study need replication and the factors driving endothelial dysfunction in patients with metabolic syndrome warrant further investigation.
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