ArticleThe Journal of membrane biology2014
Serum levels of trace elements and heavy metals in patients with acute hemorrhagic stroke.
Article in The Journal of membrane biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Serum/Plasma Zinc Is Apparently Increased in Ischemic Stroke: a Meta-analysis.Biological trace element research · 2022Pooled it
- Identification of Biomarkers Associated With Copper Metabolism in Ischemic Stroke Through Bulk RNA Sequencing and Mendelian Randomization Analysis.Cellular and molecular neurobiology · 2026Article
- Cerebrovascular accidents association between serum trace elements and toxic metals level, a case-control study.PloS one · 2025Article
- Zinc deficiency and risk of intracerebral hemorrhage: a retrospective cohort study.Frontiers in nutrition · 2025Article
- Single and mixed effects of seven heavy metals on stroke risk: 11,803 adults from National Health and Nutrition Examination Survey (NHANES).Frontiers in nutrition · 2025Article
- Cuproptosis and copper deficiency in ischemic vascular injury and repair.Apoptosis : an international journal on programmed cell death · 2024Review
- Early-Life Lead Exposure: Risks and Neurotoxic Consequences.Current medicinal chemistry · 2024Review
- Prognostic value of day-of-event serum calcium and magnesium for predicting 1-year prognosis after intracerebral hemorrhage.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Potential Role of Natural Antioxidants in Countering Reperfusion Injury in Acute Myocardial Infarction and Ischemic Stroke.Antioxidants (Basel, Switzerland) · 2023Review
- Copper homeostasis and copper-induced cell death in the pathogenesis of cardiovascular disease and therapeutic strategies.Cell death & disease · 2023Review
- Serum copper levels and risk of major adverse cardiovascular events: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2023Review
- The Important Role of Zinc in Neurological Diseases.Biomolecules · 2022Review
- Zinc's Association with the CmPn/CmP Signaling Network in Breast Cancer Tumorigenesis.Biomolecules · 2022Review
- Dietary Copper Intake and Risk of Stroke in Adults: A Case-Control Study Based on National Health and Nutrition Examination Survey 2013-2018.Nutrients · 2022Article
- Article
- Heart Failure and PAHs, OHPAHs, and Trace Elements Levels in Human Serum: Results from a Preliminary Pilot Study in Greek Population and the Possible Impact of Air Pollution.Molecules (Basel, Switzerland) · 2021Article
- Environmental heavy metals and cardiovascular diseases: Status and future direction.Chronic diseases and translational medicine · 2020Review
- Zinc Deficiency-An Independent Risk Factor in the Pathogenesis of Haemorrhagic Stroke?Nutrients · 2020Review
- Risk Factors for Stroke Based on the National Health and Nutrition Examination Survey.The journal of nutrition, health & aging · 2020Article
- Association of serum magnesium levels with risk factors, severity and prognosis in ischemic and hemorrhagic stroke patients.Caspian journal of internal medicine · 2020Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trace elements are essential components of biological structures, but alternatively, they can be toxic at concentrations beyond those necessary for their biological functions. Changes in the concentration of essential trace elements and heavy metals may affect acute hemorrhagic stroke. The aim of this study was to measure serum levels of essential trace elements [iron (Fe), zinc (Zn), manganese (Mn), copper (Cu), and magnesium (Mg)] and heavy metals [cobalt (Co), cadmium (Cd), and lead (Pb)] in patients with acute hemorrhagic stroke. Twenty-six patients with acute hemorrhagic stroke and 29 healthy controls were enrolled. Atomic absorption spectrophotometry (UNICAM-929) was used to measure serum Fe, Cu, Pb, Cd, Zn, Co, Mn and Mg concentrations. Serum Cd, Pb and Fe levels were significantly higher in patients with acute hemorrhagic stroke than controls (p < 0.001), while serum Cu, Zn, Mg and Mn levels were significantly lower (all p < 0.001). However, there was no significant difference between the groups with respect to serum Co levels (p > 0.05). We first demonstrate increased Cd, Pb, and Fe levels; and decreased Cu, Zn, Mg, and Mn levels in patients with acute hemorrhagic stroke. These findings may have diagnostic and prognostic value for acute hemorrhagic stroke. Further studies are required to elucidate the roles of trace elements and heavy metals in patients with acute hemorrhagic stroke.
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