Evidence map›Paper›PMID 24346185›Full record

ArticleNature communications2013

Phylogenetic applications of whole Y-chromosome sequences and the Near Eastern origin of Ashkenazi Levites.

Siiri Rootsi, Doron M Behar, Mari Järve, Alice A Lin, Natalie M Myres, Ben Passarelli, G David Poznik, Shay Tzur, Hovhannes Sahakyan, Ajai Kumar Pathak and 10 more

Abstract read
In one paragraph

Article in Nature communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
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  3. Epidemiology of Wilson's Disease and Pathogenic Variants of theInternational journal of molecular sciences · 2024
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  20. The phylogenetic and geographic structure of Y-chromosome haplogroup R1a.European journal of human genetics : EJHG · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Siiri Rootsi1] Estonian Biocentre and Department of Evolutionary Biology, University of Tartu, Tartu 51010, Estonia [2].
Doron M Behar1] Estonian Biocentre and Department of Evolutionary Biology, University of Tartu, Tartu 51010, Estonia [2] Molecular Medicine Laboratory, Rambam Health Care Campus, Haifa 31096, Israel [3].
Mari JärveEstonian Biocentre and Department of Evolutionary Biology, University of Tartu, Tartu 51010, Estonia.
Alice A LinDepartment of Psychiatry, Stanford University, Stanford, California 94305, USA.
Natalie M MyresAncestry.com DNA, Provo, Utah 84604, USA.
Ben PassarelliDepartment of Bioengineering, Stanford University, Stanford, California 94305, USA.
G David PoznikProgram in Biomedical Informatics and Department of Statistics, Stanford University, Stanford, California 94305, USA.
Shay TzurMolecular Medicine Laboratory, Rambam Health Care Campus, Haifa 31096, Israel.
Hovhannes Sahakyan1] Estonian Biocentre and Department of Evolutionary Biology, University of Tartu, Tartu 51010, Estonia [2] Laboratory of Ethnogenomics, Institute of Molecular Biology, National Academy of Sciences, Yerevan 0014, Armenia.
Ajai Kumar PathakEstonian Biocentre and Department of Evolutionary Biology, University of Tartu, Tartu 51010, Estonia.
Saharon RossetDepartment of Statistics and Operations Research, School of Mathematical Sciences, Tel-Aviv University, Tel-Aviv 69978, Israel.
Mait MetspaluEstonian Biocentre and Department of Evolutionary Biology, University of Tartu, Tartu 51010, Estonia.
Viola GrugniDipartimento di Biologia e Biotecnologie 'Lazzaro Spallanzani', Università di Pavia, Pavia 27100, Italy.
Ornella Semino1] Dipartimento di Biologia e Biotecnologie 'Lazzaro Spallanzani', Università di Pavia, Pavia 27100, Italy [2] Centro Interdipartimentale 'Studi di Genere', Università di Pavia, Pavia 27100, Italy.
Ene MetspaluEstonian Biocentre and Department of Evolutionary Biology, University of Tartu, Tartu 51010, Estonia.
Carlos D BustamanteDepartment of Genetics, Stanford University, Stanford, California 94305, USA.
Karl Skorecki1] Molecular Medicine Laboratory, Rambam Health Care Campus, Haifa 31096, Israel [2] Ruth and Bruce Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa 31096, Israel.
Richard Villems1] Estonian Biocentre and Department of Evolutionary Biology, University of Tartu, Tartu 51010, Estonia [2].
Toomas KivisildDivision of Biological Anthropology, University of Cambridge, CB2 3QG Cambridge, UK.
Peter A UnderhillDepartment of Genetics, Stanford University, Stanford, California 94305, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous Y-chromosome studies have demonstrated that Ashkenazi Levites, members of a paternally inherited Jewish priestly caste, display a distinctive founder event within R1a, the most prevalent Y-chromosome haplogroup in Eastern Europe. Here we report the analysis of 16 whole R1 sequences and show that a set of 19 unique nucleotide substitutions defines the Ashkenazi R1a lineage. While our survey of one of these, M582, in 2,834 R1a samples reveals its absence in 922 Eastern Europeans, we show it is present in all sampled R1a Ashkenazi Levites, as well as in 33.8% of other R1a Ashkenazi Jewish males and 5.9% of 303 R1a Near Eastern males, where it shows considerably higher diversity. Moreover, the M582 lineage also occurs at low frequencies in non-Ashkenazi Jewish populations. In contrast to the previously suggested Eastern European origin for Ashkenazi Levites, the current data are indicative of a geographic source of the Levite founder lineage in the Near East and its likely presence among pre-Diaspora Hebrews.

Indexed as

Chromosomes, Human, YGene FrequencyHaplotypesPhylogenyEurope, EasternGenetic VariationHumansJewsMalePolymorphism, Single NucleotideSequence Analysis, DNA

Identifiers

PMID24346185
PMCPMC3905698

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.