ArticleInvestigative ophthalmology & visual science2014
Intersublaminar vascular plexus: the correlation of retinal blood vessels with functional sublaminae of the inner plexiform layer.
Article in Investigative ophthalmology & visual science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Emerging strategies targeting genes and cells in glaucoma.Vision research · 2025Review
- Review
- Assessment of changes in macular structural retinal layers in patients with pathological myopia.Turkish journal of medical sciences · 2023Article
- Retinal ganglion cell dysfunction in mice following acute intraocular pressure is exacerbated by P2X7 receptor knockout.Scientific reports · 2021Article
- Optogenetic Stimulation of Cholinergic Amacrine Cells Improves Capillary Blood Flow in Diabetic Retinopathy.Investigative ophthalmology & visual science · 2020Article
- Domain-specific distribution of gap junctions defines cellular coupling to establish a vascular relay in the retina.The Journal of comparative neurology · 2019Article
- Rb is required for retinal angiogenesis and lamination.Cell death & disease · 2018Article
- Ischemia-induced spreading depolarization in the retina.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2016Article
- Leveraging Optogenetic-Based Neurovascular Circuit Characterization for Repair.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016Review
- Nonvascular retinal imaging markers of preclinical Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands) · 2016Article
- Mapping the 3D Connectivity of the Rat Inner Retinal Vascular Network Using OCT Angiography.Investigative ophthalmology & visual science · 2015Article
- Increased phosphorylation of Cx36 gap junctions in the AII amacrine cells of RD retina.Frontiers in cellular neuroscience · 2015Article
- Article
- Regulation of blood flow in the retinal trilaminar vascular network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- PI3K-mediated glioprotective effect of epidermal growth factor under oxidative stress conditions.International journal of ophthalmology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
purposeInteractions between vasculature and neurons provide important insight into the function of the nervous system, as well as into neurological diseases wherein these interactions are disrupted. This study characterizes a previously unreported retinal vascular plexus and examines potential sites of neurovascular interaction.
methodsVascular, neuronal, and glial elements were visualized using immunohistochemical markers. The distribution of vascular layers was measured and compared across eccentricities. Intensity profiles were calculated from confocal image reconstructions to reveal the proximity of vasculature to neuronal and glial processes.
resultsRetinal vasculature forms a plexus that coincides with the dendritic processes of OFF cholinergic amacrine cells within the inner plexiform layer. Across eccentricities, this plexus comprises approximately 8% of the total length of horizontally running blood vessels in the retina. Processes of Müller glia and OFF cholinergic amacrine cells colocalize with the blood vessels that form the intersublaminar plexus.
conclusionsIn the retina, vasculature lacks autonomic control, but shows efficient local regulation. Although the source of this regulation is unclear, these results suggest that cholinergic amacrine cells and Müller glia may interact with the intersublaminar plexus to influence vasomotor activity. This may indicate a key role in modulating reciprocal interactions between neuronal activity and blood flow.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.