Evidence map›Paper›PMID 24345895›Full record

ArticleTransplantation2014

Disparities in liver transplantation: the association between donor quality and recipient race/ethnicity and sex.

Amit K Mathur, Douglas E Schaubel, Hui Zhang, Mary K Guidinger, Robert M Merion

Abstract read
In one paragraph

Article in Transplantation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Racial and ethnic disparities in outcomes after heart transplantation: A systematic review of contributing factors and future directions to close the outcomes gap.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2016
    Pooled it
  2. Article
  3. Review
  4. Gender disparities in liver transplantation.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Organ Donation Willingness Among Asian Americans: Results from a National Study.Journal of racial and ethnic health disparities · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Women who undergo liver transplant have longer length of stay post-transplant compared with men.Liver international : official journal of the International Association for the Study of the Liver · 2020
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Amit K Mathur1 Section of Transplantation, Department of Surgery, University of Michigan, Ann Arbor, MI. 2 Department of Biostatistics, University of Michigan, Ann Arbor, MI. 3 Food and Drug Administration, Silver Spring, MD. 4 Department of Surgery, University of Michigan, Ann Arbor, MI. 5 Arbor Research Collaborative for Health, Ann Arbor, MI. 6 Address correspondence to: Amit K. Mathur, M.D., M.S., 2922 Taubman Center, 1500 E Medical Center Dr, SPC 5300, Ann Arbor, MI 48109-5300.
Douglas E Schaubel
Hui Zhang
Mary K Guidinger
Robert M Merion

Funding

University of Michigan Surgical Oncology Research Training ProgramT32CA009672 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JACQUELINE SARA JERUSS, WEIPING ZOU · 1991 to 2026
$6.0M
Survival Analysis Methods for Organ Failure DataR01DK070869 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI DOUGLAS EARL SCHAUBEL · 2005 to 2026
$4.7M
NCI NIH HHS T32 CA009672NCI NIH HHS T32 CA009672-18NIDDK NIH HHS 5R01DK070869NIDDK NIH HHS R01 DK070869NIMHD NIH HHS L60 MD002968NIMHD NIH HHS L60 MD002968-01
6 · The paper itself

Abstract

backgroundWe aimed to examine the association between recipient race/ethnicity and sex, donor liver quality, and liver transplant graft survival.

methodsAdult non-status 1 liver recipients transplanted between March 1, 2002, and December 31, 2008, were identified using Scientific Registry of Transplant Recipients data. The factors of interest were recipient race/ethnicity and sex. Donor risk index (DRI) was used as a donor quality measure. Logistic regression was used to assess the association between race/ethnicity and sex in relation to the transplantation of low-quality (high DRI) or high-quality (low DRI) livers. Cox regression was used to assess the association between race/ethnicity and sex and liver graft failure risk, accounting for DRI.

resultsHispanics were 21% more likely to receive low-quality grafts compared to whites (odds ratio [OR]=1.21, P=0.002). Women had greater odds of receiving a low-quality graft compared to men (OR=1.24, P<0.0001). Despite adjustment for donor quality, African American recipients still had higher graft failure rates compared to whites (hazard ratio [HR]=1.28, P<0.001). Hispanics (HR=0.89, P=0.023) had significantly lower graft failure rates compared to whites despite higher odds of receiving a higher DRI graft. Using an interaction model of DRI and race/ethnicity, we found that the impact of DRI on graft failure rates was significantly reduced for African Americans compared to whites (P=0.02).

conclusionsThis study shows that while liver graft quality differed significantly by recipient race/ethnicity and sex, donor selection practices do not seem to be the dominant factor responsible for worse liver transplant outcomes for minority recipients.

Indexed as

Graft SurvivalAdultAsianBlack or African AmericanCadaverEthnicityFemaleHealthcare DisparitiesHispanic or LatinoHumansLiver TransplantationLogistic ModelsMaleMiddle AgedProportional Hazards ModelsRisk Factors

Identifiers

PMID24345895
PMCPMC4293640

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.