ArticleJournal of pediatric gastroenterology and nutrition2014
Depression subtypes in pediatric inflammatory bowel disease.
Article in Journal of pediatric gastroenterology and nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Association between depression and anxiety with the risk and flare of inflammatory bowel disease: a systematic review and meta-analysis.Internal and emergency medicine · 2025Pooled it
- Fatigue in children and adolescents with inflammatory bowel disease.World journal of gastroenterology · 2019Pooled it
- Effect of Psychotherapy on Health Care Utilization in Children With Inflammatory Bowel Disease and Depression.Journal of pediatric gastroenterology and nutrition · 2016Trial
- Effects of a Cognitive Behavioral Therapy Intervention Trial to Improve Disease Outcomes in Children with Inflammatory Bowel Disease.Inflammatory bowel diseases · 2016Trial
- Effect of 2 psychotherapies on depression and disease activity in pediatric Crohn's disease.Inflammatory bowel diseases · 2015Trial
- Randomized efficacy trial of two psychotherapies for depression in youth with inflammatory bowel disease.Journal of the American Academy of Child and Adolescent Psychiatry · 2014Trial
- Transition Failure in Pediatric Inflammatory Bowel Disease: An Underrecognized Determinant of Long-Term Outcomes.Children (Basel, Switzerland) · 2026Review
- Adolescent and caregiver perceptions of addressing mental health in inflammatory bowel disease.Journal of child health care : for professionals working with children in the hospital and community · 2025Article
- The 2023 Impact of Inflammatory Bowel Disease in Canada: Mental Health and Inflammatory Bowel Disease.Journal of the Canadian Association of Gastroenterology · 2023Review
- Shifting Health Care Use from Hospitalisations and Surgeries to Outpatient Visits in Children with Inflammatory Bowel Disease: A Population-based Cohort Study from Ontario, Canada.Journal of Crohn's & colitis · 2021Article
- Review
- Association of Care Coordination Experience and Health Services Use with Main Provider Type for Children with Inflammatory Bowel Disease.The Journal of pediatrics · 2021Article
- Evaluating a Standardized Transition of Care Process for Pediatric Inflammatory Bowel Disease Patients.Children (Basel, Switzerland) · 2020Article
- Microbiota-gut-brain axis and its affect inflammatory bowel disease: Pathophysiological concepts and insights for clinicians.World journal of clinical cases · 2020Review
- Biopsychosocial Correlates of Presence and Intensity of Pain in Adolescents With Inflammatory Bowel Disease.Frontiers in pediatrics · 2020Article
- Illness Perceptions and Depression Are Associated with Health-Related Quality of Life in Youth with Inflammatory Bowel Disease.International journal of behavioral medicine · 2019Article
- Depression Is Associated With More Aggressive Inflammatory Bowel Disease.The American journal of gastroenterology · 2018Article
- Interventions to Support Integrated Psychological Care and Holistic Health Outcomes in Paediatrics.Healthcare (Basel, Switzerland) · 2017Review
- Psychological Factors May Play an Important Role in Pediatric Crohn's Disease Symptoms and Disability.The Journal of pediatrics · 2017Article
- Considering the Bidirectional Pathways Between Depression and IBD: Recommendations for Comprehensive IBD Care.Gastroenterology & hepatology · 2017Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveThe association between inflammatory bowel disease (IBD) and depression provides a unique opportunity to understand the relation between systemic inflammation and depressive symptom profiles.
methodsYouth (n = 226) ages 9 to 17 years with comorbid IBD and depression underwent psychiatric assessment and evaluation of IBD activity. Latent profile analysis (LPA) identified depressive subgroups based on similar responses to the Children's Depression Rating Scale-Revised. Demographic factors, depression severity, anxiety, IBD activity, inflammatory markers, IBD-related medications, and illness perception were evaluated as predictors of profile membership.
resultsMean age was 14.3 years; 75% had Crohn disease; 31% were taking systemic corticosteroids. Mean depressive severity was moderate, whereas IBD activity, which reflects inflammation, was mild. LPA identified 3 subgroups: Profile-1 (mild, 75%) had diverse low-grade depressive symptoms and highest quality of life; Profile-2 (somatic, 19%) had severe fatigue, appetite change, anhedonia, decreased motor activity, and depressed mood with concurrent high-dose steroid therapy and the highest IBD activity; and Profile-3 (cognitive, 6%) had the highest rates of self-reported depressive symptoms, ostomy placements, and anxiety with IBD symptoms in the relative absence of inflammation.
conclusionsEvidence was found for 3 depression profiles in youth with IBD and depression. Our analyses determined that patients with predominantly somatic or cognitive symptoms of depression comprised 25% of our cohort. These findings may be used to design subgroup-specific interventions for depression in adolescents with IBD and other physical illnesses associated with systemic inflammation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.