ArticleMucosal immunology2014
Hypertrophy of infected Peyer's patches arises from global, interferon-receptor, and CD69-independent shutdown of lymphocyte egress.
Article in Mucosal immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- Type 3 innate lymphoid cells dominate the ILC compartment in endstage lung disease.Frontiers in immunology · 2026Article
- Intestinal microbiota regulates naïve lymphocyte migration in Peyer's patches.Frontiers in immunology · 2025Article
- Rotavirus infection causes mesenteric lymph node hypertrophy independently of type I interferon or TNF-α in mice.European journal of immunology · 2021Article
- Lymphatic endothelial cells of the lymph node.Nature reviews. Immunology · 2020Review
- Robo4 contributes to the turnover of Peyer's patch B cells.Mucosal immunology · 2020Article
- Efficient homing of T cells via afferent lymphatics requires mechanical arrest and integrin-supported chemokine guidance.Nature communications · 2020Article
- Traditional Processed Meat Products Re-designed Towards Inulin-rich Functional Foods Reduce Polyps in Two Colorectal Cancer Animal Models.Scientific reports · 2019Article
- Chikungunya virus impairs draining lymph node function by inhibiting HEV-mediated lymphocyte recruitment.JCI insight · 2018Article
- Kcnn4 is a modifier gene of intestinal cystic fibrosis preventing lethality in the Cftr-F508del mouse.Scientific reports · 2018Article
- Lymph node γδ and αβ CD8Scientific reports · 2018Article
- Photoconversion of Alloreactive T Cells in Murine Peyer's Patches During Acute Graft-Versus-Host Disease: Tracking the Homing Route of Highly Proliferative CellsFrontiers in immunology · 2018Article
- CD69: from activation marker to metabolic gatekeeper.European journal of immunology · 2017Review
- Distinct mechanisms of B and T lymphocyte accumulation generate tumor-draining lymph node hypertrophy.Oncoimmunology · 2016Article
- Live cell imaging to understand monocyte, macrophage, and dendritic cell function in atherosclerosis.The Journal of experimental medicine · 2016Review
- Peyer's patches: organizing B-cell responses at the intestinal frontier.Immunological reviews · 2016Review
- Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota.Nature immunology · 2015Article
- Regulation of antiviral T cell responses by type I interferons.Nature reviews. Immunology · 2015Review
- CD69 is the crucial regulator of intestinal inflammation: a new target molecule for IBD treatment?Journal of immunology research · 2015Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lymphoid organ hypertrophy is a hallmark of localized infection. During the inflammatory response, massive changes in lymphocyte recirculation and turnover boost lymphoid organ cellularity. Intriguingly, the exact nature of these changes remains undefined to date. Here, we report that hypertrophy of Salmonella-infected Peyer's patches (PPs) ensues from a global "shutdown" of lymphocyte egress, which traps recirculating lymphocytes in PPs. Surprisingly, infection-induced lymphocyte sequestration did not require previously proposed mediators of lymphoid organ shutdown including type I interferon receptor and CD69. In contrast, following T-cell receptor-mediated priming, CD69 was essential to selectively block CD4(+) effector T-cell egress. Our findings segregate two distinct lymphocyte sequestration mechanisms, which differentially rely on intrinsic modulation of lymphocyte egress capacity and inflammation-induced changes in the lymphoid organ environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.