Evidence map›Paper›PMID 24345750›Full record

ArticleBlood2014

Monoclonal B-cell lymphocytosis in healthy blood donors: an unexpectedly common finding.

Youn K Shim, Jane M Rachel, Paolo Ghia, Jeff Boren, Fatima Abbasi, Antonis Dagklis, Geri Venable, Jiyeon Kang, Heba Degheidy, Fred V Plapp and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 73 citations in OpenAlex.

  1. Article
  2. Review
  3. Observational
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
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  15. Review
  16. Pathogenesis of chronic lymphocytic leukemia and the development of novel therapeutic strategies.Journal of clinical and experimental hematopathology : JCEH · 2020
    Review
  17. Observational
  18. Article
  19. CD4+CD8+ Double-Positive T-Lymphocytes: PitfallsTurkish journal of haematology : official journal of Turkish Society of Haematology · 2020
    Article
  20. Clonal Hematopoiesis in Related Allogeneic Transplant Donors: Implications for Screening and Management.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 2 countries.

Youn K ShimDivision of Toxicology and Human Health Sciences, Agency for Toxic Substances and Disease Registry, Atlanta, GA;
Jane M Rachel
Paolo Ghia
Jeff Boren
Fatima Abbasi
Antonis Dagklis
Geri Venable
Jiyeon Kang
Heba Degheidy
Fred V Plapp
Robert F Vogt
Jay E Menitove
Gerald E Marti
St. Vincent's Medical Center · USCenter for Biologics Evaluation and Research · USAgency for Toxic Substances and Disease Registry · USMolecular Oncology (United States) · USNational Center for Environmental Health · USUnited States Food and Drug Administration · USVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circulating monoclonal B cells may be detected in healthy adults, a condition called monoclonal B-cell lymphocytosis (MBL). MBL has also been identified in donated blood, but no systematic study of blood donors has been reported. Using sensitive and specific laboratory methods, we detected MBL in 149 (7.1%; 95% confidence interval, 6.0% to 8.3%) of 2098 unique donors ages 45 years or older in a Midwestern US regional blood center between 2010 and 2011. Most of the 149 donors had low-count MBL, including 99 chronic lymphocytic leukemia-like (66.4%), 22 atypical (14.8%), and 19 CD5(-) (12.8%) immunophenotypes. However, 5 donors (3.4%) had B-cell clonal counts above 500 cells per µL, including 3 with 1693 to 2887 cells per µL; the clone accounted for nearly all their circulating B cells. Four donors (2.7%) had 2 distinct MBL clones. Of 51 MBL samples in which immunoglobulin heavy chain (IGH)V-D-J genotypes could be determined, 71% and 29% used IGHV3- and IGHV4-family genes, respectively. Sequencing revealed 82% with somatic hypermutation, whereas 18% had >98% germ-line identity, including 5 with entirely germ-line sequences. In conclusion, MBL prevalence is much higher in blood donors than previously reported, and although uncommon, the presence of high-count MBL warrants further investigations to define the biological fate of the transfused cells in recipients.

Indexed as

AgedAged, 80 and overAntibodies, MonoclonalBlood DonorsB-LymphocytesFemaleHumansImmunoglobulin Heavy ChainsImmunophenotypingLeukemia, Lymphocytic, Chronic, B-CellLymphocyte CountLymphocytosisMaleMiddle AgedPrevalenceAntibodies, MonoclonalImmunoglobulin Heavy Chains

Identifiers

PMID24345750
PMCPMC3938146
OpenAlexW1992396683

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.