ArticleBiomaterials2014
Postnatal epithelium and mesenchyme stem/progenitor cells in bioengineered amelogenesis and dentinogenesis.
Article in Biomaterials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- The effect of BMP4, FGF8 and WNT3a on mouse iPS cells differentiating to odontoblast-like cells.Medical molecular morphology · 2022Article
- Exosomes released from educated mesenchymal stem cells accelerate cutaneous wound healing via promoting angiogenesis.Cell proliferation · 2020Article
- LGR5Cell death & disease · 2020Article
- Parenchymal and stromal tissue regeneration of tooth organ by pivotal signals reinstated in decellularized matrix.Nature materials · 2019Article
- The role of stem cell therapy in regeneration of dentine-pulp complex: a systematic review.Progress in biomaterials · 2018Review
- Article
- The potential of enriched mesenchymal stem cells with neural crest cell phenotypes as a cell source for regenerative dentistry.The Japanese dental science review · 2017Review
- Oral Mucosa Harbors a High Frequency of Endothelial Cells: A Novel Postnatal Cell Source for Angiogenic Regeneration.Stem cells and development · 2017Article
- Hair Germ Model In Vitro via Human Postnatal Keratinocyte-Dermal Papilla Interactions: Impact of Hyaluronic Acid.Stem cells international · 2017Article
- Wnt/β-Catenin Regulates the Activity of Epiprofin/Sp6, SHH, FGF, and BMP to Coordinate the Stages of Odontogenesis.Frontiers in cell and developmental biology · 2016Article
- Article
- Lhx8 mediated Wnt and TGFβ pathways in tooth development and regeneration.Biomaterials · 2015Article
- Mesenchymal dental pulp cells attenuate dentin resorption in homeostasis.Journal of dental research · 2015Article
- BMP7 and EREG Contribute to the Inductive Potential of Dental Mesenchyme.Scientific reports · 2015Article
- Wnt5a regulates dental follicle stem/progenitor cells of the periodontium.Stem cell research & therapy · 2014Article
- MSX2 in ameloblast cell fate and activity.Frontiers in physiology · 2014Review
- DNA methylation profile is associated with the osteogenic potential of three distinct human odontogenic stem cells.Signal transduction and targeted therapyArticle
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Rodent incisors provide a classic model for studying epithelial-mesenchymal interactions in development. However, postnatal stem/progenitor cells in rodent incisors have not been exploited for tooth regeneration. Here, we characterized postnatal rat incisor epithelium and mesenchyme stem/progenitor cells and found that they formed enamel- and dentin-like tissues in vivo. Epithelium and mesenchyme cells were harvested separately from the apical region of postnatal 4-5 day rat incisors. Epithelial and mesenchymal phenotypes were confirmed by immunocytochemistry, CFU assay and/or multi-lineage differentiation. CK14+, Sox2+ and Lgr5+ epithelium stem cells from the cervical loop enhanced amelogenin and ameloblastin expression upon BMP4 or FGF3 stimulation, signifying their differentiation towards ameloblast-like cells, whereas mesenchyme stem/progenitor cells upon BMP4, BMP7 and Wnt3a treatment robustly expressed Dspp, a hallmark of odontoblastic differentiation. We then control-released microencapsulated BMP4, BMP7 and Wnt3a in transplants of epithelium and mesenchyme stem/progenitor cells in the renal capsule of athymic mice in vivo. Enamel and dentin-like tissues were generated in two integrated layers with specific expression of amelogenin and ameloblastin in the newly formed, de novo enamel-like tissue, and DSP in dentin-like tissue. These findings suggest that postnatal epithelium and mesenchyme stem/progenitor cells can be primed towards bioengineered tooth regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.