Trial reportThe Journal of clinical psychiatry2014
A randomized trial of concurrent smoking-cessation and substance use disorder treatment in stimulant-dependent smokers.
Trial report in The Journal of clinical psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01077024 (Smoking-Cessation and Stimulant Treatment), which is not on this map. Cited by 43 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Smoking-Cessation and Stimulant Treatment (S-CAST): Evaluation of the Impact of Concurrent Outpatient Smoking-Cessation and Stimulant Treatment on Stimulant-Dependence Outcomes
Who cites it
43 citing papers in PubMed, 10 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Incentives for smoking cessation.The Cochrane database of systematic reviews · 2025Pooled it
- Comparative clinical effectiveness and safety of tobacco cessation pharmacotherapies and electronic cigarettes: a systematic review and network meta-analysis of randomized controlled trials.Addiction (Abingdon, England) · 2022Pooled it
- Pharmacological Treatment of Methamphetamine/Amphetamine Dependence: A Systematic Review.CNS drugs · 2020Pooled it
- Incentives for smoking cessation.The Cochrane database of systematic reviews · 2019Pooled it
- Competitions for smoking cessation.The Cochrane database of systematic reviews · 2019Pooled it
- Interventions for tobacco use cessation in people in treatment for or recovery from substance use disorders.The Cochrane database of systematic reviews · 2016Pooled it
- A Systematic Review of Smoking Cessation Interventions for Adults in Substance Abuse Treatment or Recovery.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2016Pooled it
- Combined pharmacotherapy and behavioural interventions for smoking cessation.The Cochrane database of systematic reviews · 2016Pooled it
- Treating tobacco use disorder in pregnant women in medication-assisted treatment for an opioid use disorder: a systematic review.Journal of substance abuse treatment · 2015Pooled it
- The ASAM/AAAP Clinical Practice Guideline on the Management of Stimulant Use Disorder.Journal of addiction medicineGuideline
- Prize-Based Incentives for Smoking Cessation Among People With HIV: A Sequential Multiple Assignment Randomized Trial.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025Trial
- Naltrexone plus bupropion reduces cigarette smoking in individuals with methamphetamine use disorder: A secondary analysis from the CTN ADAPT-2 trial.Journal of substance use and addiction treatment · 2023Trial
- Sequential and simultaneous treatment approaches to cannabis use disorder and tobacco use.Journal of substance abuse treatment · 2019Trial
- Substance use outcomes in cocaine-dependent tobacco smokers: A mediation analysis exploring the role of sleep disturbance, craving, anxiety, and depression.Journal of substance abuse treatment · 2019Trial
- Hair analysis and its concordance with self-report for drug users presenting in emergency department.Drug and alcohol dependence · 2016Trial
- Evaluating Nicotine Craving, Withdrawal, and Substance Use as Mediators of Smoking Cessation in Cocaine- and Methamphetamine-Dependent Patients.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2016Trial
- The coupling of nicotine and stimulant craving during treatment for stimulant dependence.Journal of consulting and clinical psychology · 2016Trial
- Concurrent alcohol and tobacco treatment: Effect on daily process measures of alcohol relapse risk.Journal of consulting and clinical psychology · 2015Trial
- Achieving smoking abstinence is associated with decreased cocaine use in cocaine-dependent patients receiving smoking-cessation treatment.Drug and alcohol dependence · 2014Trial
- A tale of two stimulants: mentholated cigarettes may play a role in cocaine, but not methamphetamine, dependence.Drug and alcohol dependence · 2013Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 9 institutions in 3 countries.
Funding
Abstract
objectiveTo evaluate the impact of concurrent treatments for substance use disorder and nicotine-dependence for stimulant-dependent patients.
methodA randomized, 10-week trial with follow-up at 3 and 6 months after smoking quit date conducted at 12 substance use disorder treatment programs between February 2010 and July 2012. Adults meeting DSM-IV-TR criteria for cocaine and/or methamphetamine dependence and interested in quitting smoking were randomized to treatment as usual (n = 271) or treatment as usual with smoking-cessation treatment (n = 267). All participants received treatment as usual for substance use disorder treatment. Participants assigned to treatment as usual with concurrent smoking-cessation treatment received weekly individual smoking cessation counseling and extended-release bupropion (300 mg/d) during weeks 1-10. During post-quit treatment (weeks 4-10), participants assigned to treatment as usual with smoking-cessation treatment received a nicotine inhaler and contingency management for smoking abstinence. Weekly proportion of stimulant-abstinent participants during the treatment phase, as assessed by urine drug screens and self-report, was the primary outcome. Secondary measures included other substance/nicotine use outcomes and treatment attendance.
resultsThere were no significant treatment effects on stimulant-use outcomes, as measured by the primary outcome and stimulant-free days, on drug-abstinence, or on attendance. Participants assigned to treatment as usual with smoking-cessation treatment, relative to those assigned to treatment as usual, had significantly better outcomes for drug-free days at 6-month follow-up (χ(2)(1) = 4.09, P <.05), with a decrease in drug-free days from baseline of -1.3% in treatment as usual with smoking-cessation treatment and of -7.6% in treatment as usual. Participants receiving treatment as usual with smoking-cessation treatment, relative to those receiving treatment as usual, had significantly better outcomes on smoking point-prevalence abstinence (25.5% vs 2.2%; χ(2)(1) = 44.69, P < .001; OR =18.2).
conclusionsThese results suggest that providing smoking-cessation treatment to illicit stimulant-dependent patients in outpatient substance use disorder treatment will not worsen, and may enhance, abstinence from nonnicotine substance use.
trial registrationClinicalTrials.gov identifier: NCT01077024.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.