Evidence map›Paper›PMID 24345328›Full record

ArticleEnvironmental health perspectives2014

Evaluating the effectiveness of fish consumption advisories: modeling prenatal, postnatal, and childhood exposures to persistent organic pollutants.

Matthew J Binnington, Cristina L Quinn, Michael S McLachlan, Frank Wania

Abstract read
In one paragraph

Article in Environmental health perspectives, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Serum concentrations of PCBs and OCPs among prepubertal Korean children.Environmental science and pollution research international · 2016
    Article
  5. New approaches in human health risk assessment.International journal of circumpolar health · 2016
    Article
  6. An update on risk communication in the Arctic.International journal of circumpolar health · 2016
    Review
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Matthew J BinningtonDepartment of Physical and Environmental Sciences, University of Toronto Scarborough, Toronto, Ontario, Canada.
Cristina L Quinn
Michael S McLachlan
Frank Wania

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBecause human exposure to persistent organic pollutants (POPs) occurs mainly through ingestion of contaminated food, regulatory bodies issue dietary consumption advisories to describe safe intake levels for food items of concern, particularly fish.

objectivesOur study goal was to estimate the effectiveness of fish consumption advisories in reducing exposure of infants and children to POPs.

methodsWe used the time-variant mechanistic model CoZMoMAN to estimate and compare prenatal, postnatal, and childhood exposure to polychlorinated biphenyl congener PCB-153 under different scenarios of maternal guideline adherence for both hypothetical constant and realistic time-variant chemical emissions. The scenarios differed in terms of length of compliance (1 vs. 5 years), extent of fish substitution (all vs. half), and replacement diet (uncontaminated produce vs. beef). We also estimated potential exposure reductions for a range of theoretical chemicals to explore how guideline effectiveness varies with a chemical's partitioning and degradation properties.

resultsWhen assuming realistic time periods of advisory compliance, our findings suggest that temporarily eliminating or reducing maternal fish consumption is largely ineffective in reducing pre- and postnatal exposure to substances with long elimination half-lives in humans, especially during periods of decreasing environmental emissions. Substituting fish with beef may actually result in higher exposure to certain groups of environmental contaminants. On the other hand, advisories may be highly effective in reducing exposure to substances with elimination half-lives in humans shorter than the length of compliance.

conclusionsOur model estimates suggest that fish consumption advisories are unlikely to be effective in reducing prenatal, postnatal, and childhood exposures to compounds with long elimination half-lives in humans.

Indexed as

Models, BiologicalNutrition PolicyAnimalsChildEnvironmental ExposureEnvironmental PollutantsFemaleFishesFood ContaminationHumansInfant, NewbornPatient CompliancePolychlorinated BiphenylsPregnancyTime Factors2,4,5,2',4',5'-hexachlorobiphenylEnvironmental PollutantsPolychlorinated Biphenyls

Identifiers

PMID24345328
PMCPMC3915257

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.