SynthesisBMC pediatrics2013
Clinical prediction models for bronchopulmonary dysplasia: a systematic review and external validation study.
Synthesis in BMC pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Bronchopulmonary dysplasia prediction models: a systematic review and meta-analysis with validation.Pediatric research · 2023Pooled it
- Prediction Models for Bronchopulmonary Dysplasia in Preterm Infants: A Systematic Review.Frontiers in pediatrics · 2022Pooled it
- Development of a peripheral blood transcriptomic gene signature to predict bronchopulmonary dysplasia.American journal of physiology. Lung cellular and molecular physiology · 2023Trial
- Should Vitamin A Injections to Prevent Bronchopulmonary Dysplasia or Death Be Reserved for High-Risk Infants? Reanalysis of the National Institute of Child Health and Human Development Neonatal Research Network Randomized Trial.The Journal of pediatrics · 2021Trial
- Bronchopulmonary Dysplasia and Perinatal Characteristics Predict 1-Year Respiratory Outcomes in Newborns Born at Extremely Low Gestational Age: A Prospective Cohort Study.The Journal of pediatrics · 2017Trial
- Early Cumulative Supplemental Oxygen Predicts Bronchopulmonary Dysplasia in High Risk Extremely Low Gestational Age Newborns.The Journal of pediatrics · 2016Trial
- Comparisons and Limitations of Current Definitions of Bronchopulmonary Dysplasia for the Prematurity and Respiratory Outcomes Program.Annals of the American Thoracic Society · 2015Trial
- Intra-breath respiratory oscillometry in the first days of life in preterm infants: a prospective observational study.European journal of pediatrics · 2026Observational
- Does more granular data equal better bronchopulmonary dysplasia prediction?Pediatric research · 2026Article
- Umbilical cord blood cell transcriptional and methylation signatures at birth are associated with BPD development and chorioamnionitis: a pilot study.Scientific reports · 2026Article
- Tissue Doppler Imaging, Pulmonary Haemodynamics and Conventional Echocardiographic Indices for Early Bronchopulmonary Dysplasia Prediction in Preterm Infants: A Prospective Observational Feasibility Study.Children (Basel, Switzerland) · 2026Article
- A Respiratory Intervention Intensity Index for Supplemental Oxygen Use at Postnatal Day 28 in Preterm Infants Using BWQS Regression: Incremental Stratification Beyond Gestational Age in a Single-Center Retrospective Cohort Study.Journal of multidisciplinary healthcare · 2026Article
- Early prediction of bronchopulmonary dysplasia: comparison of modelling methods, development and validation studies.Pediatric research · 2026Article
- Early multi-system physiological biomarkers of bronchopulmonary dysplasia in preterm infants: a matched case-control study based on bedside monitoring.Frontiers in medicine · 2026Article
- Umbilical Cord Blood Cell Transcriptional and Methylation Signatures at Birth Are Associated with BPD Development.bioRxiv : the preprint server for biology · 2025Article
- Deep learning-based prediction of cardiopulmonary disease in retinal images of premature infants.medRxiv : the preprint server for health sciences · 2025Article
- Oxygenation Instability and Short-Term Morbidities Among Very-Low-Birthweight Premature Infants.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Development and validation of a prediction model for bronchopulmonary dysplasia using respiratory severity score.Pediatric research · 2025Article
- Can we really predict the respiratory morbidity of preterm birth?Pediatric research · 2025Article
- Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors.
Funding
Abstract
backgroundBronchopulmonary dysplasia (BPD) is a common complication of preterm birth. Very different models using clinical parameters at an early postnatal age to predict BPD have been developed with little extensive quantitative validation. The objective of this study is to review and validate clinical prediction models for BPD.
methodsWe searched the main electronic databases and abstracts from annual meetings. The STROBE instrument was used to assess the methodological quality. External validation of the retrieved models was performed using an individual patient dataset of 3229 patients at risk for BPD. Receiver operating characteristic curves were used to assess discrimination for each model by calculating the area under the curve (AUC). Calibration was assessed for the best discriminating models by visually comparing predicted and observed BPD probabilities.
resultsWe identified 26 clinical prediction models for BPD. Although the STROBE instrument judged the quality from moderate to excellent, only four models utilised external validation and none presented calibration of the predictive value. For 19 prediction models with variables matched to our dataset, the AUCs ranged from 0.50 to 0.76 for the outcome BPD. Only two of the five best discriminating models showed good calibration.
conclusionsExternal validation demonstrates that, except for two promising models, most existing clinical prediction models are poor to moderate predictors for BPD. To improve the predictive accuracy and identify preterm infants for future intervention studies aiming to reduce the risk of BPD, additional variables are required. Subsequently, that model should be externally validated using a proper impact analysis before its clinical implementation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.