Evidence map›Paper›PMID 24345303›Full record

ReviewNeuromodulation : journal of the International Neuromodulation Society2014

Surgical neuroanatomy and programming in deep brain stimulation for obsessive compulsive disorder.

Takashi Morishita, Sarah M Fayad, Wayne K Goodman, Kelly D Foote, Dennis Chen, David A Peace, Albert L Rhoton, Michael S Okun

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuromodulation : journal of the International Neuromodulation Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Deep brain stimulation for treatment-resistant depression: systematic review of clinical outcomes.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2014
    Pooled it
  2. Article
  3. Article
  4. Behavioral disorders in Parkinson disease: current view.Journal of neural transmission (Vienna, Austria : 1996) · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Optimizing Deep Brain Stimulation Parameters in Obsessive-Compulsive Disorder.Neuromodulation : journal of the International Neuromodulation Society · 2021
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. It takes time to tune.Annals of translational medicine · 2017
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Takashi MorishitaDepartment of Neurosurgery, University of Florida College of Medicine/Shands Hospital, Center for Movement Disorders and Neurorestoration, McKnight Brain Institute, Gainesville, FL, USA.
Sarah M Fayad
Wayne K Goodman
Kelly D Foote
Dennis Chen
David A Peace
Albert L Rhoton
Michael S Okun

Funding

WHITE MATTER AND COGNITION IN PARKINSON'S DISEASEM01RR000082 · NCRR · UNIVERSITY OF FLORIDA · PI BYRNE, BARRY J · 1985 to 2009
$29.7M
Pilot Study of DBS for Treatment-Refractory OCDR21MH064161 · NIMH · UNIVERSITY OF FLORIDA · PI WARD, HERBERT E · 2002 to 2006
$1.1M
NCRR NIH HHS M01 RR000082NIMH NIH HHS R21 MH064161
6 · The paper itself

Abstract

objectivesDeep brain stimulation (DBS) has been established as a safe, effective therapy for movement disorders (Parkinson's disease, essential tremor, etc.), and its application is expanding to the treatment of other intractable neuropsychiatric disorders including depression and obsessive-compulsive disorder (OCD). Several published studies have supported the efficacy of DBS for severely debilitating OCD. However, questions remain regarding the optimal anatomic target and the lack of a bedside programming paradigm for OCD DBS. Management of OCD DBS can be highly variable and is typically guided by each center's individual expertise. In this paper, we review the various approaches to targeting and programming for OCD DBS. We also review the clinical experience for each proposed target and discuss the relevant neuroanatomy. MATERIALS AND

methodsA PubMed review was performed searching for literature on OCD DBS and included all articles published before March 2012. We included all available studies with a clear description of the anatomic targets, programming details, and the outcomes.

resultsSix different DBS approaches were identified. High-frequency stimulation with high voltage was applied in most cases, and predictive factors for favorable outcomes were discussed in the literature.

conclusionDBS remains an experimental treatment for medication refractory OCD. Target selection and programming paradigms are not yet standardized, though an improved understanding of the relationship between the DBS lead and the surrounding neuroanatomic structures will aid in the selection of targets and the approach to programming. We propose to form a registry to track OCD DBS cases for future clinical study design.

Indexed as

BrainDeep Brain StimulationElectrodes, ImplantedHumansObsessive-Compulsive DisorderTreatment OutcomeDeep brain stimulationinferior thalamic peduncleobsessive compulsive disordersubthalamic nucleusventral capsule/ventral striatum

Identifiers

PMID24345303
PMCPMC4061279

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.