Trial reportJournal of cognitive neuroscience2014
Dissociating motivation from reward in human striatal activity.
Trial report in Journal of cognitive neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A feature-based network analysis and fMRI meta-analysis reveal three distinct types of prosocial decisions.Social cognitive and affective neuroscience · 2021Pooled it
- The anticipation and outcome phases of reward and loss processing: A neuroimaging meta-analysis of the monetary incentive delay task.Human brain mapping · 2018Pooled it
- Methamphetamine alters nucleus accumbens neural activation to monetary loss in healthy young adults.Psychopharmacology · 2023Trial
- Distinct Reward Properties are Encoded via Corticostriatal Interactions.Scientific reports · 2016Trial
- Erotic stimulus processing under amisulpride and reboxetine: a placebo-controlled fMRI study in healthy subjects.The international journal of neuropsychopharmacology · 2014Trial
- Functional segregation in Parkinson's disease.Science advances · 2026Article
- Blunted reward-related striatal activity and behavioral disinhibition as a pathway to adolescent cannabis and e-cigarette use.Frontiers in adolescent medicine · 2026Article
- Motivational neurobehavioral abnormalities under a naturalistic goal-conflict task in patients with premenstrual dysphoric disorder.Frontiers in psychiatry · 2026Article
- Subcortical nuclei of the human ascending arousal system encode anticipated reward but do not predict subsequent memory.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Methamphetamine enhances neural activation during anticipation of loss in the monetary incentive delay task.Cerebral cortex communications · 2023Article
- Long-term stability of single neuron activity in the motor system.Nature neuroscience · 2022Article
- Alternations in Dynamic and Static Functional Connectivity Density in Chronic Smokers.Frontiers in psychiatry · 2022Article
- How we decide what to eat: Toward an interdisciplinary model of gut-brain interactions.Wiley interdisciplinary reviews. Cognitive science · 2022Review
- Investigating the Relationship between White Matter Connectivity and Motivational Circuits in Subjects with Deficit Schizophrenia: A Diffusion Tensor Imaging (DTI) Study.Journal of clinical medicine · 2021Article
- Avoiding monetary loss: A human habenula functional MRI ultra-high field study.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- Promising vulnerability markers of substance use and misuse: A review of human neurobehavioral studies.Neuropharmacology · 2021Review
- The basal ganglia and the cerebellum in human emotion.Social cognitive and affective neuroscience · 2020Review
- Neurostructural correlates of optimism: Gray matter density in the putamen predicts dispositional optimism in late adolescence.Human brain mapping · 2020Article
- Goal congruency dominates reward value in accounting for behavioral and neural correlates of value-based decision-making.Nature communications · 2019Article
- Striatal responsiveness to reward under threat-of-shock and working memory load: A preliminary study.Brain and behavior · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Neural activity in the striatum has consistently been shown to scale with the value of anticipated rewards. As a result, it is common across a number of neuroscientific subdiscliplines to associate activation in the striatum with anticipation of a rewarding outcome or a positive emotional state. However, most studies have failed to dissociate expected value from the motivation associated with seeking a reward. Although motivation generally scales positively with increases in potential reward, there are circumstances in which this linkage does not apply. The current study dissociates value-related activation from that induced by motivation alone by employing a task in which motivation increased as anticipated reward decreased. This design reverses the typical relationship between motivation and reward, allowing us to differentially investigate fMRI BOLD responses that scale with each. We report that activity scaled differently with value and motivation across the striatum. Specifically, responses in the caudate and putamen increased with motivation, whereas nucleus accumbens activity increased with expected reward. Consistent with this, self-report ratings indicated a positive association between caudate and putamen activity and arousal, whereas activity in the nucleus accumbens was more associated with liking. We conclude that there exist regional limits on inferring reward expectation from striatal activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.