Trial reportJournal of cognitive neuroscience2014
Love to win or hate to Lose? Asymmetry of dopamine D2 receptor binding predicts sensitivity to reward versus punishment.
Trial report in Journal of cognitive neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Decisional incentive sensitivity is linked to contingency management outcome and striatal dopamine signaling in individuals with cocaine use disorder: a preliminary study.Addiction and substance abuse · 2026Article
- Change in motivational bias during treatment predicts outcome in anorexia nervosa.The International journal of eating disorders · 2024Article
- Understanding Emotions: Origins and Roles of the Amygdala.Biomolecules · 2021Review
- Hemispheric asymmetries in resting-state EEG and fMRI are related to approach and avoidance behaviour, but not to eating behaviour or BMI.Human brain mapping · 2020Article
- D2 receptors and cognitive flexibility in marmosets: tri-phasic dose-response effects of intra-striatal quinpirole on serial reversal performance.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Article
- Left-shifting prism adaptation boosts reward-based learning.Cortex; a journal devoted to the study of the nervous system and behavior · 2018Article
- Executive (dys)function after traumatic brain injury: special considerations for behavioral pharmacology.Behavioural pharmacology · 2018Review
- Age affects reinforcement learning through dopamine-based learning imbalance and high decision noise-not through Parkinsonian mechanisms.Neurobiology of aging · 2018Article
- Individual differences in dopamine DCognitive, affective & behavioral neuroscience · 2018Article
- To Do or Not to Do: Dopamine, Affordability and the Economics of Opportunity.Frontiers in integrative neuroscience · 2018Article
- Individual Differences in Reward Sensitivity Modulate the Distinctive Effects of Conscious and Unconscious Rewards on Executive Performance.Frontiers in psychology · 2018Article
- "You Win, You Buy"-How Continuous Win Effect Influence Consumers' Price Perception: An ERP Study.Frontiers in neuroscience · 2018Article
- Distinct neural processes support post-success and post-error slowing in the stop signal task.Neuroscience · 2017Article
- Linking dopaminergic reward signals to the development of attentional bias: A positron emission tomographic study.NeuroImage · 2017Article
- Article
- Altered reward expectancy in individuals with recent methamphetamine dependence.Journal of psychopharmacology (Oxford, England) · 2017Article
- EEG marker of inhibitory brain activity correlates with resting-state cerebral blood flow in the reward system in major depression.European archives of psychiatry and clinical neuroscience · 2016Article
- Interoception, homeostatic emotions and sympathovagal balance.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Article
- Hints on the Lateralization of Dopamine Binding to D1 Receptors in Rat Striatum.Molecular neurobiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Humans show consistent differences in the extent to which their behavior reflects a bias toward appetitive approach-related behavior or avoidance of aversive stimuli [Elliot, A. J. Approach and avoidance motivation. In A. J. Elliot (Ed.), Handbook of approach and avoidance motivation (pp. 3-14). New York: Psychology Press, 2008]. We examined the hypothesis that in healthy participants this motivational bias (assessed by self-report and by a probabilistic learning task that allows direct comparison of the relative sensitivity to reward and punishment) reflects lateralization of dopamine signaling. Using [F-18]fallypride to measure D2/D3 binding, we found that self-reported motivational bias was predicted by the asymmetry of frontal D2 binding. Similarly, striatal and frontal asymmetries in D2 dopamine receptor binding, rather than absolute binding levels, predicted individual differences in learning from reward versus punishment. These results suggest that normal variation in asymmetry of dopamine signaling may, in part, underlie human personality and cognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.