ArticleBehavioral and brain functions : BBF2013
Experimental gastritis leads to anxiety- and depression-like behaviors in female but not male rats.
Article in Behavioral and brain functions : BBF, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Pepsinogen II and a no-pickled food diet are risk factors for female patients with anxiety: a cross-sectional study.American journal of translational research · 2024Article
- Evaluation of the Effects of Instant Cascara Beverage on the Brain-Gut Axis of Healthy Male and Female Rats.Nutrients · 2023Article
- Promising effect of Geranium robertianum L. leaves and Aloe vera gel powder on AspirinInflammopharmacology · 2023Article
- Sex differences in residual somatic symptoms in patients with first-episode depression after acute-phase treatment.BMC psychiatry · 2023Article
- Global trends in research related to functional dyspepsia and anxiety or depression over the past two decades: a bibliometric analysis.Frontiers in neuroscience · 2023Article
- In search of sex-related mediators of affective illness.Biology of sex differences · 2021Review
- Chronic stress accelerates the process of gastric precancerous lesions in rats.Journal of Cancer · 2021Article
- Sex Differences in the Gut-Brain Axis: Implications for Mental Health.Current psychiatry reports · 2020Review
- Gender Differences in Stress- and Burnout-Related Factors of University Professors.BioMed research international · 2020Article
- Neurobiological mechanisms underlying sex-related differences in stress-related disorders: Effects of neuroactive steroids on the hippocampus.Frontiers in neuroendocrinology · 2019Review
- Reward Processing under Chronic Pain from the Perspective of "Liking" and "Wanting": A Narrative Review.Pain research & management · 2019Review
- Protective effect of aspirin treatment on mouse behavior in the acute phase of experimental infection with Trypanosoma cruzi.Parasitology research · 2018Article
- Review
- Hedonic and motivational responses to food reward are unchanged in rats with neuropathic pain.Pain · 2016Article
- Chronic Nonmodulated Microwave Radiations in Mice Produce Anxiety-like and Depression-like Behaviours and Calcium- and NO-related Biochemical Changes in the Brain.Experimental neurobiology · 2016Article
- Gender Differences in the Neurobiology of Anxiety: Focus on Adult Hippocampal Neurogenesis.Neural plasticity · 2016Review
- Gut-Brain Axis in Gastric Mucosal Damage and Protection.Current neuropharmacology · 2016Review
- High Times for Painful Blues: The Endocannabinoid System in Pain-Depression Comorbidity.The international journal of neuropsychopharmacology · 2015Review
- Neighborhood epidemiological monitoring and adult mental health: European Quality of Life Survey, 2007-2012.Environmental science and pollution research international · 2015Article
- Short-term effect of acute and repeated urinary bladder inflammation on thigmotactic behaviour in the laboratory rat.F1000Research · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human and animals studies support the idea that there is a gender-related co-morbidity of pain-related and inflammatory gastrointestinal (GI) diseases with psychological disorders. This co-morbidity is the evidence for the existence of GI-brain axis which consists of immune (cytokines), neural (vagus nerve) and neuroendocrine (HPA axis) pathways. Psychological stress causes disturbances in GI physiology, such as altered GI barrier function, changes in motility and secretion, development of visceral hypersensitivity, and dysfunction of inflammatory responses. Whether GI inflammation would exert impact on psychological behavior is not well established. We examined the effect of experimental gastritis on anxiety- and depression-like behaviors in male and female Sprague-Dawley rats, and evaluated potential mechanisms of action. Gastritis was induced by adding 0.1% (w/v) iodoacetamide (IAA) to the sterile drinking water for 7 days. Sucrose preference test assessed the depression-like behavior, open field test and elevated plus maze evaluated the anxiety-like behavior. IAA treatment induced gastric inflammation in rats of either gender. No behavioral abnormality or dysfunction of GI-brain axis was observed in male rats with IAA-induced gastritis. Anxiety- and depression-like behaviors were apparent and the HPA axis was hyperactive in female rats with IAA-induced gastritis. Our results show that gastric inflammation leads to anxiety- and depression-like behaviors in female but not male rats via the neuroendocrine (HPA axis) pathway, suggesting that the GI inflammation can impair normal brain function and induce changes in psychological behavior in a gender-related manner through the GI-to-brain signaling.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.