ArticleProceedings of the National Academy of Sciences of the United States of America2014
Alloreactive cytotoxic T cells provide means to decipher the immunopeptidome and reveal a plethora of tumor-associated self-epitopes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Targeting the roots of myeloid malignancies with T cell receptors.Nature reviews. Cancer · 2025Review
- A T cell receptor targeting a recurrent driver mutation in FLT3 mediates elimination of primary human acute myeloid leukemia in vivo.Nature cancer · 2023Article
- CIMT 2021: report on the 18th Annual Meeting of the Association for Cancer Immunotherapy.Human vaccines & immunotherapeutics · 2022Article
- T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes.Nature biotechnology · 2022Article
- Novel myeloperoxidase-derived HLA-A2-restricted peptides as therapeutic targets against myeloid leukemia.Cytotherapy · 2021Article
- Murine Leukemia-Derived Extracellular Vesicles Elicit Antitumor Immune Response.Journal of blood medicine · 2021Article
- Human ovarian cancer intrinsic mechanisms regulate lymphocyte activation in response to immune checkpoint blockade.Cancer immunology, immunotherapy : CII · 2020Article
- Presence of T cells directed against CD20-derived peptides in healthy individuals and lymphoma patients.Cancer immunology, immunotherapy : CII · 2019Article
- A tissue-based draft map of the murine MHC class I immunopeptidome.Scientific data · 2018Article
- Targeting PR1 in myeloid leukemia.Oncotarget · 2018Article
- Article
- Induction of anti-leukemic responses by stimulation of leukemic CD3+ cells with allogeneic stimulator cells.Experimental hematology & oncology · 2018Article
- How an alloreactive T-cell receptor achieves peptide and MHC specificity.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Impact of Depleting Therapeutic Monoclonal Antibodies on the Host Adaptive Immunity: A Bonus or a Malus?Frontiers in immunology · 2017Review
- Graft versus self (GvS) against T-cell autoantigens is a mechanism of graft-host interaction.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Targeting B-cell neoplasia with T-cell receptors recognizing a CD20-derived peptide on patient-specific HLA.Oncoimmunology · 2016Article
- T-cell receptor gene therapy--ready to go viral?Molecular oncology · 2015Review
- Analysis of Major Histocompatibility Complex (MHC) Immunopeptidomes Using Mass Spectrometry.Molecular & cellular proteomics : MCP · 2015Review
- Trial Watch: Peptide-based anticancer vaccines.Oncoimmunology · 2015Review
- Protein networks and activation of lymphocytes.Current opinion in immunology · 2015Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
HLA molecules presenting peptides derived from tumor-associated self-antigens (self-TAA) are attractive targets for T-cell-based immunotherapy of cancer. However, detection of such epitopes is hampered by self-tolerance and limitations in the sensitivity of mass spectrometry. Here, we used T cells from HLA-A2-negative donors as tools to detect HLA-A2-bound peptides from two leukemia-associated differentiation antigens; CD20 and the previously undescribed cancer target myeloperoxidase. A high-throughput platform for epitope discovery was designed using dendritic cells cotransfected with full-length transcripts of self-TAA and HLA-A2 to allow presentation of all naturally processed peptides from a predefined self-protein on foreign HLA. Antigen-reactive T cells were directly detected using panels of color-coded peptide-HLA multimers containing epitopes predicted by a computer algorithm. Strikingly, cytotoxic T cells were generated against 37 out of 50 peptides predicted to bind HLA-A2. Among these, 36 epitopes were previously undescribed. The allorestricted T cells were exquisitely peptide- and HLA-specific and responded strongly to HLA-A2-positive leukemic cells with endogenous expression of CD20 or myeloperoxidase. These results indicate that the repertoire of self-peptides presented on HLA class I has been underestimated and that a wealth of self-TAA can be targeted by T cells when using nontolerized T-cell repertoires.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.