ArticleLearning & memory (Cold Spring Harbor, N.Y.)2013
The ubiquitin-specific protease 14 (USP14) is a critical regulator of long-term memory formation.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Association Between Proteasome 26S Subunit, Non-ATPase 3 Methylation and Insulin β Cell Apoptosis in Type 2 Diabetic Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Review
- Usp14 deficiency removes α-synuclein by regulating S100A8/A9 in Parkinson's disease.Cellular and molecular life sciences : CMLS · 2024Article
- Proteotoxic stress and the ubiquitin proteasome system.Seminars in cell & developmental biology · 2024Review
- PROTACs technology for treatment of Alzheimer's disease: Advances and perspectives.Acta materia medica · 2022Article
- Is PROTAC technology really a game changer for central nervous system drug discovery?Expert opinion on drug discovery · 2021Article
- Males and females differ in the regulation and engagement of, but not requirement for, protein degradation in the amygdala during fear memory formation.Neurobiology of learning and memory · 2021Article
- USP14: Structure, Function, and Target Inhibition.Frontiers in pharmacology · 2021Review
- Deficiency of the CYLD Impairs Fear Memory of Mice and Disrupts Neuronal Activity and Synaptic Transmission in the Basolateral Amygdala.Frontiers in cellular neuroscience · 2021Article
- USP14 as a Therapeutic Target Against Neurodegeneration: A Rat Brain Perspective.Frontiers in cell and developmental biology · 2020Article
- NADCell metabolism · 2019Review
- Overexpression of ubiquitin specific peptidase 14 predicts unfavorable prognosis in esophageal squamous cell carcinoma.Thoracic cancer · 2017Article
- PTRHD1 (C2orf79) mutations lead to autosomal-recessive intellectual disability and parkinsonism.Movement disorders : official journal of the Movement Disorder Society · 2017Article
- Proteolysis, synaptic plasticity and memory.Neurobiology of learning and memory · 2017Review
- CaMKII regulates proteasome phosphorylation and activity and promotes memory destabilization following retrieval.Neurobiology of learning and memory · 2016Article
- The Ubiquitin-Proteasome System: Potential Therapeutic Targets for Alzheimer's Disease and Spinal Cord Injury.Frontiers in molecular neuroscience · 2016Review
- ER stress: Autophagy induction, inhibition and selection.Autophagy · 2015Article
- A 5.8 Mb interstitial deletion on chromosome Xq21.1 in a boy with intellectual disability, cleft palate, hearing impairment and combined growth hormone deficiency.BMC medical genetics · 2015Article
- Epigenetic mechanisms of memory formation and reconsolidation.Neurobiology of learning and memory · 2014Review
- Epigenetic regulation of estrogen-dependent memory.Frontiers in neuroendocrinology · 2014Review
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Numerous studies have suggested a role for ubiquitin-proteasome-mediated protein degradation in learning-dependent synaptic plasticity; however, very little is known about how protein degradation is regulated at the level of the proteasome during memory formation. The ubiquitin-specific protease 14 (USP14) is a proteasomal deubiquitinating enzyme that is thought to regulate protein degradation in neurons; however, it is unknown if USP14 is involved in learning-dependent synaptic plasticity. We found that infusion of a USP14 inhibitor into the amygdala impaired long-term memory for a fear conditioning task, suggesting that USP14 is a critical regulator of long-term memory formation in the amygdala.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.