ArticleLearning & memory (Cold Spring Harbor, N.Y.)2013
The 5-HT3A receptor is essential for fear extinction.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- The Role of Serotonin in Brain Development: From Molecular Pathways to Neurodevelopmental Risk.Cellular and molecular neurobiology · 2026Review
- Serotonin Modulation of Dorsoventral Hippocampus in Physiology and Schizophrenia.International journal of molecular sciences · 2025Review
- Cannabinoids and monoaminergic system: implications for learning and memory.Frontiers in neuroscience · 2024Review
- A Novel and Functionally Diverse Class of Acetylcholine-Gated Ion Channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Neuronal pericellular baskets: neurotransmitter convergence and regulation of network excitability.Trends in neurosciences · 2021Review
- Deorphanization of novel biogenic amine-gated ion channels identifies a new serotonin receptor for learning.Current biology : CB · 2021Article
- Article
- Upregulated NMDAR-mediated GABAergic transmission underlies autistic-like deficits inTheranostics · 2021Article
- Development-Dependent Plasticity in Vasoactive Intestinal Polypeptide Neurons in the Infralimbic Cortex.Cerebral cortex communications · 2021Article
- Renoprotective and neuroprotective effects of enteric hydrogen generation from Si-based agent.Scientific reports · 2020Article
- Single-cell RNA-Seq characterization of anatomically identified OLM interneurons in different transgenic mouse lines.The European journal of neuroscience · 2019Article
- A novel 5HT3 receptor-IGF1 mechanism distinct from SSRI-induced antidepressant effects.Molecular psychiatry · 2018Article
- Neurobiology of fear and specific phobias.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Review
- Contribution of Hippocampal 5-HTCellular and molecular neurobiology · 2017Article
- Building a 5-HT3A Receptor Expression Map in the Mouse Brain.Scientific reports · 2017Article
- The quantum universe: philosophical foundations and oriental medicine.Integrative medicine research · 2016Review
- Transcriptional Coactivator and Chromatin Protein PC4 Is Involved in Hippocampal Neurogenesis and Spatial Memory Extinction.The Journal of biological chemistry · 2016Article
- Authentic role of ATP signaling in micturition reflex.Scientific reports · 2016Article
- The 5-HT3 receptor is essential for exercise-induced hippocampal neurogenesis and antidepressant effects.Molecular psychiatry · 2015Article
- 5-HT1B autoreceptors differentially modulate the expression of conditioned fear in a circuit-specific manner.Neuroscience · 2015Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The 5-HT3 receptor, the only ionotropic 5-HT receptor, is expressed in limbic regions, including the hippocampus, amygdala, and cortex. However, it is not known whether it has a role in fear memory processes. Analysis of 5-HT3A receptor knockout mice in fear conditioning paradigms revealed that the 5-HT3A receptor is not required for the acquisition or retention of fear memory but is essential for the extinction of contextual and tone-cued fear. Our data suggest that the 5-HT3A receptor could be a key molecule regulating fear memory processes and a potential therapeutic target for fear disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.