ArticleThe Journal of physiology2014
Carbachol excites sublaterodorsal nucleus neurons projecting to the spinal cord.
Article in The Journal of physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Are noradrenergics combined with antimuscarinics the future pharmacologic treatment for obstructive sleep apnea? A systematic review and meta-analysis of randomized controlled trials.Sleep & breathing = Schlaf & Atmung · 2024Pooled it
- A Narrative Review on REM Sleep Deprivation: A Promising Non-Pharmaceutical Alternative for Treating Endogenous Depression.Journal of personalized medicine · 2023Review
- Effects of bupropion and SSRI antidepressants on leg movement activity and chin muscle tone during sleep in adolescents.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Article
- Neurophysiological Aspects of REM Sleep Behavior Disorder (RBD): A Narrative Review.Brain sciences · 2021Review
- Sleep-Wake Neurobiology.Advances in experimental medicine and biology · 2021Review
- The Relationship of Rapid Eye Movement Sleep Behavior Disorder and Freezing of Gait in Parkinson's Disease.Cureus · 2020Review
- Orexin signaling modulates synchronized excitation in the sublaterodorsal tegmental nucleus to stabilize REM sleep.Nature communications · 2020Article
- Arousal and sleep circuits.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Review
- Diversity of reticulospinal systems in mammals.Current opinion in physiology · 2019Article
- Molecular Mechanisms of REM Sleep.Frontiers in neuroscience · 2019Review
- Ventral medullary control of rapid eye movement sleep and atonia.Experimental neurology · 2017Article
- Neural Circuitry of Wakefulness and Sleep.Neuron · 2017Review
- The anatomical, cellular and synaptic basis of motor atonia during rapid eye movement sleep.The Journal of physiology · 2016Review
- Neuroscience: A Distributed Neural Network Controls REM Sleep.Current biology : CB · 2016Article
- Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- REM Sleep at its Core - Circuits, Neurotransmitters, and Pathophysiology.Frontiers in neurology · 2015Review
- Endogenous cholinergic input to the pontine REM sleep generator is not required for REM sleep to occur.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Cholinergic involvement in control of REM sleep paralysis.The Journal of physiology · 2014Article
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Abstract
Considerable electrophysiological and pharmacological evidence has long suggested an important role for acetylcholine in the regulation of rapid-eye-movement (REM) sleep. For example, injection of the cholinergic agonist carbachol into the dorsomedial pons produces an REM sleep-like state with muscle atonia and cortical activation, both of which are cardinal features of REM sleep. Located within this region of the pons is the sublaterodorsal nucleus (SLD), a structure thought to be both necessary and sufficient for generating REM sleep muscle atonia. Subsets of glutamatergic SLD neurons potently contribute to motor inhibition during REM sleep through descending projections to motor-related glycinergic/GABAergic neurons in the spinal cord and ventromedial medulla. Prior electrophysiological and pharmacological studies examining the effects of acetylcholine on SLD neurons have, however, produced conflicting results. In the present study, we sought to clarify how acetylcholine influences the activity of spinally projecting SLD (SLDsp) neurons. We used retrograde tracing in combination with patch-clamp recordings and recorded pre- and postsynaptic effects of carbachol on SLDsp neurons. Carbachol acted presynaptically by increasing the frequency of glutamatergic miniature excitatory postsynaptic currents. We also found that carbachol directly excited SLDsp neurons by activating an Na(+)-Ca(2+) exchanger. Both pre- and postsynaptic effects were mediated by co-activation of M1 and M3 muscarinic receptors. These observations suggest that acetylcholine produces synergistic, excitatory pre- and postsynaptic responses on SLDsp neurons that, in turn, probably serve to promote muscle atonia during REM sleep.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.