ArticlePediatrics2014
Association between pediatric clinical trials and global burden of disease.
Article in Pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Recent trends and structural patterns in NIH pediatric research funding, 2015-2024.Pediatric research · 2026Article
- The usefulness of orthopedic shoulder surgery randomized controlled trials: are they meeting the key criteria?JSES reviews, reports, and techniques · 2025Article
- Prioritization of Randomized Clinical Trial Questions for Children Hospitalized With Common Conditions: A Consensus Statement.JAMA network open · 2024Article
- Closing the critical care knowledge gap: the importance of publications from low-income and middle-income countries.Critical care science · 2024Article
- Article
- Pediatric biobanks to enhance clinical and translational research for children.European journal of pediatrics · 2023Review
- The CAPNET multi-center data set for child physical abuse: Rationale, methods and scope.Child abuse & neglect · 2022Article
- Challenges in conducting paediatric trials with off-patent drugs.Contemporary clinical trials communications · 2021Article
- Publication Trends of Pediatric and Adult Randomized Controlled Trials in General Medical Journals, 2005-2018: A Citation Analysis.Children (Basel, Switzerland) · 2020Article
- Fake news and fake research: Why meta-research matters more than ever.Journal of paediatrics and child health · 2020Article
- Global Disparities Between Pediatric Publications and Disease Burden From 2006 to 2015.Global pediatric health · 2019Article
- Pediatric Trials Run in India: An Analysis of Clinical Trials.gov 2006-2015.Indian journal of pediatrics · 2019Review
- Neglected tropical diseases in children: An assessment of gaps in research prioritization.PLoS neglected tropical diseases · 2019Article
- Lifetime Cost of Abusive Head Trauma at Ages 0-4, USA.Prevention science : the official journal of the Society for Prevention Research · 2018Article
- The institutional development award states pediatric clinical trials network: building research capacity among the rural and medically underserved.Current opinion in pediatrics · 2018Review
- Protocol for a scoping review to map evidence from randomised controlled trials on paediatric eye disease to disease burden.Systematic reviews · 2017Article
- A child abuse research network: Now what?Child abuse & neglect · 2017Article
- Research priorities for a multi-center child abuse pediatrics network - CAPNET.Child abuse & neglect · 2017Article
- Update on Trial Registration 11 Years after the ICMJE Policy Was Established.The New England journal of medicine · 2017Article
- Automatic classification of registered clinical trials towards the Global Burden of Diseases taxonomy of diseases and injuries.BMC bioinformatics · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundThe allocation of research resources should favor conditions responsible for the greatest disease burden. This is particularly important in pediatric populations, which have been underrepresented in clinical research. Our aim was to measure the association between the focus of pediatric clinical trials and burden of disease and to identify neglected clinical domains.
methodsWe performed a cross-sectional study of clinical trials by using trial records in ClinicalTrials.gov. All trials started in 2006 or after and studying patient-level interventions in pediatric populations were included. Age-specific measures of disease burden were obtained for 21 separate conditions for high-, middle-, and low-income countries. We measured the correlation between number of pediatric clinical trials and disease burden for each condition.
resultsNeuropsychiatric conditions and infectious diseases were the most studied conditions globally in terms of number of trials (874 and 847 trials, respectively), while intentional injuries (5 trials) and maternal conditions (4 trials) were the least studied. Clinical trials were only moderately correlated with global disease burden (r = 0.58, P = .006). Correlations were also moderate within each of the country income levels, but lowest in low-income countries (r = .47, P = .03). Globally, the conditions most understudied relative to disease burden were injuries (-260 trials for unintentional injuries and -160 trials for intentional injuries), nutritional deficiencies (-175 trials), and respiratory infections (-171 trials).
conclusionsPediatric clinical trial activity is only moderately associated with pediatric burden of disease, and least associated in low-income countries. The mismatch between clinical trials and disease burden identifies key clinical areas for focus and investment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.