Evidence map›Paper›PMID 24343547›Full record

SynthesisThe American journal of gastroenterology2014

Development of an online library of patient-reported outcome measures in gastroenterology: the GI-PRO database.

Puja Khanna, Nikhil Agarwal, Dinesh Khanna, Ron D Hays, Lin Chang, Roger Bolus, Gil Melmed, Cynthia B Whitman, Robert M Kaplan, Rikke Ogawa and 2 more

Abstract readComparative StudySystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The American journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
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  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
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  11. Observational
  12. Review
  13. Gastrointestinal Manifestations of Systemic Sclerosis.Rheumatology (Sunnyvale, Calif.) · 2018
    Article
  14. Article
  15. Article
  16. Development and validation of a disease-targeted quality of life instrument for chronic diverticular disease: the DV-QOL.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2015
    Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Puja KhannaDivision of Rheumatology, University of Michigan, Ann Arbor, Michigan, USA.
Nikhil Agarwal1] Department of Gastroenterology, VA Greater Los Angeles Healthcare System, Los Angeles, California, USA [2] Department of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Dinesh KhannaDivision of Rheumatology, University of Michigan, Ann Arbor, Michigan, USA.
Ron D HaysDivision of General Internal Medicine and Health Services Research, David Geffen School of Medicine at UCLA, and Department of Health Services, UCLA School of Public Health, Los Angeles, California, USA.
Lin Chang1] Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, California, USA [2] Center for Neurobiology of Stress, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Roger Bolus1] Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, California, USA [2] UCLA/VA Center for Outcomes Research and Education, Los Angeles, California, USA.
Gil MelmedDepartment of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Cynthia B WhitmanUCLA/VA Center for Outcomes Research and Education, Los Angeles, California, USA.
Robert M KaplanDivision of General Internal Medicine and Health Services Research, David Geffen School of Medicine at UCLA, and Department of Health Services, UCLA School of Public Health, Los Angeles, California, USA.
Rikke OgawaBiomedical Library of the Health Sciences, University of California at Los Angeles, California, USA.
Bradley SnyderUCLA/VA Center for Outcomes Research and Education, Los Angeles, California, USA.
Brennan Mr Spiegel1] Department of Gastroenterology, VA Greater Los Angeles Healthcare System, Los Angeles, California, USA [2] Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine at UCLA, and Department of Health Services, UCLA School of Public Health, Los Angeles, California, USA [3] Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, California, USA [4] UCLA/VA Center for Outcomes Research and Education, Los Angeles, California, USA.

Funding

The Center for Health Improvement of Minority ElderlyP30AG021684 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Homero Erwin del Pino · 2002 to 2026
$19.7M
TRAINING COREP20MD000182 · NIMHD · CHARLES R. DREW UNIVERSITY OF MED &SCI · PI CUNNINGHAM, WILLIAM EMERY, SHAPIRO, MARTIN F. · 2002 to 2016
$16.5M
NIH PROMIS Statistical Coordinating Center(RMI)U01AR052177 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CELLA, DAVID · 2004 to 2010
$10.6M
UCLA OLDER AMERICANS INDEPENDENCE CENTERP30AG028748 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MOORE, ALISON AHERN · 2006 to 2017
$9.8M
Development and Initial Validation of PROMIS GI Distress ScaleU01AR057936 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KHANNA, DINESH, SPIEGEL, BRENNAN · 2009 to 2013
$2.2M
Outcomes Research in Rheumatic DiseasesK24AR063120 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KHANNA, DINESH · 2012 to 2022
$1.6M
NIAMS NIH HHS AR052177NIAMS NIH HHS K24 AR063120NIAMS NIH HHS U01 AR052177NIAMS NIH HHS U01 AR057936NIAMS NIH HHS U01 AR057936ANIA NIH HHS P30 AG021684NIA NIH HHS P30 AG028748NIMHD NIH HHS P20 MD000182
6 · The paper itself

Abstract

objectivesBecause gastrointestinal (GI) illnesses can cause physical, emotional, and social distress, patient-reported outcomes (PROs) are used to guide clinical decision making, conduct research, and seek drug approval. It is important to develop a mechanism for identifying, categorizing, and evaluating the over 100 GI PROs that exist. Here we describe a new, National Institutes of Health (NIH)-supported, online PRO clearinghouse-the GI-PRO database.

methodsUsing a protocol developed by the NIH Patient-Reported Outcome Measurement Information System (PROMIS(®)), we performed a systematic review to identify English-language GI PROs. We abstracted PRO items and developed an online searchable item database. We categorized symptoms into content "bins" to evaluate a framework for GI symptom reporting. Finally, we assigned a score for the methodological quality of each PRO represented in the published literature (0-20 range; higher indicates better).

resultsWe reviewed 15,697 titles (κ>0.6 for title and abstract selection), from which we identified 126 PROs. Review of the PROs revealed eight GI symptom "bins": (i) abdominal pain, (ii) bloat/gas, (iii) diarrhea, (iv) constipation, (v) bowel incontinence/soilage, (vi) heartburn/reflux, (vii) swallowing, and (viii) nausea/vomiting. In addition to these symptoms, the PROs covered four psychosocial domains: (i) behaviors, (ii) cognitions, (iii) emotions, and (iv) psychosocial impact. The quality scores were generally low (mean 8.88 ± 4.19; 0 (min)-20 (max). In addition, 51% did not include patient input in developing the PRO, and 41% provided no information on score interpretation.

conclusionsGI PROs cover a wide range of biopsychosocial symptoms. Although plentiful, GI PROs are limited by low methodological quality. Our online PRO library (www.researchcore.org/gipro/) can help in selecting PROs for clinical and research purposes.

Indexed as

Databases as TopicInternetOutcome Assessment, Health CareSelf DisclosureFemaleGastroenterologyGastrointestinal DiseasesHumansInformation SystemsMaleMedical InformaticsNational Institutes of Health (U.S.)Quality of LifeUnited States

Identifiers

PMID24343547
PMCPMC4275098

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.