ArticleCellular and molecular life sciences : CMLS2014
Choroid plexus implants rescue Alzheimer's disease-like pathologies by modulating amyloid-β degradation.
Article in Cellular and molecular life sciences : CMLS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Association of choroid plexus volume with white matter microstructure, glymphatic function, and peripheral systemic inflammation in Alzheimer's disease.Translational psychiatry · 2025Article
- Approaches for Increasing Cerebral Efflux of Amyloid-β in Experimental Systems.Journal of Alzheimer's disease : JAD · 2024Review
- Amyloid-β slows cilia movement along the ventricle, impairs fluid flow, and exacerbates its neurotoxicity in explant culture.Scientific reports · 2023Article
- The Blood-Cerebrospinal Fluid Barrier May Play a Role in Alzheimer Disease Pathogenesis.Radiology · 2022Article
- Choroid Plexus in Alzheimer's Disease-The Current State of Knowledge.Biomedicines · 2022Review
- Organ Culture and Grafting of Choroid Plexus into the Ventricular CSF of Normal and Hydrocephalic HTx Rats.Journal of neuropathology and experimental neurology · 2020Article
- Choroid plexus and the blood-cerebrospinal fluid barrier in disease.Fluids and barriers of the CNS · 2020Review
- Choroid plexus volume is associated with levels of CSF proteins: relevance for Alzheimer's and Parkinson's disease.Neurobiology of aging · 2020Article
- Molecular Bases of Alzheimer's Disease and Neurodegeneration: The Role of Neuroglia.Aging and disease · 2018Review
- The choroid plexus as a site of damage in hemorrhagic and ischemic stroke and its role in responding to injury.Fluids and barriers of the CNS · 2017Review
- Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles.EMBO molecular medicine · 2016Article
- The choroid plexus-cerebrospinal fluid interface in Alzheimer's disease: more than just a barrier.Neural regeneration research · 2016Review
- Gene expression and functional annotation of human choroid plexus epithelium failure in Alzheimer's disease.BMC genomics · 2015Article
- Encapsulated Choroid Plexus Epithelial Cells Actively Protect Against Intrahippocampal Aβ-induced Long-Term Memory Dysfunction; Upregulation of Effective Neurogenesis with the Abrogated Apoptosis and Neuroinflammation.Journal of molecular neuroscience : MN · 2015Article
- Choroid plexus in developmental and evolutionary perspective.Frontiers in neuroscience · 2014Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The choroid plexuses (CP) release numerous biologically active enzymes and neurotrophic factors, and contain a subpopulation of neural progenitor cells providing the capacity to proliferate and differentiate into other types of cells. These characteristics make CP epithelial cells (CPECs) excellent candidates for cell therapy aiming at restoring brain tissue in neurodegenerative illnesses, including Alzheimer's disease (AD). In the present study, using in vitro approaches, we demonstrated that CP were able to diminish amyloid-β (Aβ) levels in cell cultures, reducing Aβ-induced neurotoxicity. For in vivo studies, CPECs were transplanted into the brain of the APP/PS1 murine model of AD that exhibits advanced Aβ accumulation and memory impairment. Brain examination after cell implantation revealed a significant reduction in brain Aβ deposits, hyperphosphorylation of tau, and astrocytic reactivity. Remarkably, the transplantation of CPECs was accompanied by a total behavioral recovery in APP/PS1 mice, improving spatial and non-spatial memory. These findings reinforce the neuroprotective potential of CPECs and the use of cell therapies as useful tools in AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.