ArticleAnesthesiology2013
Effect of catechol-o-methyltransferase-gene (COMT) variants on experimental and acute postoperative pain in 1,000 women undergoing surgery for breast cancer.
Article in Anesthesiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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19 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Systematic review of genetic polymorphisms associated with psychoneurological symptoms in breast cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Pooled it
- Selection of opioids for cancer-related pain using a biomarker: a randomized, multi-institutional, open-label trial (RELIEF study).BMC cancer · 2017Trial
- Modeling Pain Without Injury: Inherited Rodent Models as Mechanistic Windows into Chronic Pain.Function (Oxford, England) · 2025Review
- Association of COMT rs4680 Genotype With Chronic Neuropathic Pain Experience in Patients With Sickle Cell Disease.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2025Article
- Pharmacogenomics of oxycodone: a narrative literature review.Pharmacogenomics · 2021Review
- Opioid-induced Somatic Activation: Prevalence in a Population of Patients With Chronic Pain.Cureus · 2020Article
- Association of G472A allele of membrane bound catechol-O-methyltransferase gene with chronic post-sternotomy pain.General thoracic and cardiovascular surgery · 2019Article
- Genetic Variants Associated with Cancer Pain and Response to Opioid Analgesics: Implications for Precision Pain Management.Seminars in oncology nursing · 2019Review
- To predict sufentanil requirement for postoperative pain control using a real-time method: A prospective observational cohort study.Medicine · 2016Observational
- Common variants of catechol-O-methyltransferase influence patient-controlled analgesia usage and postoperative pain in patients undergoing total hysterectomy.The pharmacogenomics journal · 2016Article
- MAPK1/ERK2 as novel target genes for pain in head and neck cancer patients.BMC genetics · 2016Article
- COMT gene locus: new functional variants.Pain · 2015Article
- Alternative Splicing of G Protein-Coupled Receptors: Relevance to Pain Management.Mayo Clinic proceedings · 2015Review
- Association of genetic and psychological factors with persistent pain after cosmetic thoracic surgery.Journal of pain research · 2015Article
- Association of ADRB1 gene polymorphisms with pain sensitivity in a Chinese population.International journal of clinical and experimental medicine · 2015Article
- Effect of gene polymorphism of COMT and OPRM1 on the preoperative pain sensitivity in patients with cancer.International journal of clinical and experimental medicine · 2015Article
- Is the experience of thermal pain genetics dependent?BioMed research international · 2015Review
- Article
- COMT gene variants and β-endorphin levels contribute to ethnic differences in experimental pain sensitivity.Molecular painObservational
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6 authors at 1 institution in 1 country.
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Abstract
backgroundCatechol-O-methyltransferase (COMT) metabolizes catecholamines in different tissues. Polymorphisms in COMT gene can attenuate COMT activity and increase sensitivity to pain. Human studies exploring the effect of COMT polymorphisms on pain sensitivity have mostly included small, heterogeneous samples and have ignored several important single nucleotide polymorphisms (SNPs). This study examines the effect of COMT polymorphisms on experimental and postoperative pain phenotypes in a large ethnically homogeneous female patient cohort.
methodsIntensity of cold (+2-4°C) and heat (+48°C) pain and tolerance to cold pain were assessed in 1,000 patients scheduled for breast cancer surgery. Acute postoperative pain and oxycodone requirements were recorded. Twenty-two COMT SNPs were genotyped and their association with six pain phenotypes analyzed with linear regression.
resultsThere was no association between any of the tested pain phenotypes and SNP rs4680. The strongest association signals were seen between rs165774 and heat pain intensity as well as rs887200 and cold pain intensity. In both cases, minor allele carriers reported less pain. Neither of these results remained significant after strict multiple testing corrections. When analyzed further, the effect of rs887200 was, however, shown to be significant and consistent throughout the cold pressure test. No evidence of association between the SNPs and postoperative oxycodone consumption was found.
conclusionsSNPs rs887200 and rs165774 located in the untranslated regions of the gene had the strongest effects on pain sensitivity. Their effect on pain is described here for the first time. These results should be confirmed in further studies and the potential functional mechanisms of the variants studied.
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