ArticleAnesthesiology2013
Pain in 1,000 women treated for breast cancer: a prospective study of pain sensitivity and postoperative pain.
Article in Anesthesiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02487524 (Biomarkers of Neuropathic Pain in Women Treated for Breast Cancer), which is not on this map. Cited by 45 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Biomarkers of Neuropathic Pain in Women Treated for Breast Cancer
Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 113 citations in OpenAlex.
- Novel Prevention Approaches of Breast Cancer Surgery Related Complications: Systematic Review and Network Meta-Analysis.Asian Pacific journal of cancer prevention : APJCP · 2024Pooled it
- Pooled it
- Trial
- Does individual pain threshold influence postoperative pain after connective tissue graft surgery?Clinical oral investigations · 2026Article
- Comprehensive antigen profiling predicts post-surgical neuropathic pain in women treated for breast cancer.Scientific reports · 2026Article
- Breast Cancer Cell Lines AT-3 and E0771 Decrease Mechanical and Cold Sensitivity, Along With Oestrous Cycle and Inflammatory Marker Alterations, in Wild-Type C57BL/6J Female Mice.European journal of pain (London, England) · 2025Article
- A scoping review of pain and tobacco use among cancer survivors.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025Article
- Predictors and influence of postoperative moderate-to-severe pain of PACU in the patients with malignancy.BMC anesthesiology · 2024Article
- NTHL1 is a recessive cancer susceptibility gene.Scientific reports · 2023Article
- Predictors of postoperative pain six months after breast surgery.Scientific reports · 2023Article
- Pain-related and psychological factors mediate the effect of personality on health-related quality of life. A study in breast cancer survivors with persistent pain.Frontiers in psychology · 2023Article
- Evidence-Based Guideline on the Prevention and Management of Perioperative Pain for Breast Cancer Peoples in a Low-Resource Setting: A Systematic Review Article.Anesthesiology research and practice · 2023Review
- Exploring the Effect of Pain Sensitive Questionnaire on Guiding Intravenous Analgesia After Cesarean Section: A Randomised Double Blind Controlled Trial.Journal of pain research · 2023Article
- Article
- Implementation of CYP2D6 copy-number imputation panel and frequency of key pharmacogenetic variants in Finnish individuals with a psychotic disorder.The pharmacogenomics journal · 2022Article
- Machine-Learning Analysis of Serum Proteomics in Neuropathic Pain after Nerve Injury in Breast Cancer Surgery Points at Chemokine Signaling via SIRT2 Regulation.International journal of molecular sciences · 2022Article
- Incidence and risk factors for chronic postsurgical pain following video-assisted thoracoscopic surgery: a retrospective study.BMC surgery · 2022Article
- Measuring emotional preoperative stress by an app approach and its applicability to predict postoperative pain.PloS one · 2022Article
- Nomogram prediction of chronic postsurgical pain in patients with lung adenocarcinoma after video-assisted thoracoscopic surgery: A prospective study.Frontiers in surgery · 2022Article
- Chronic pain after breast surgery: incidence, associated factors, and impact on quality of life, an observational prospective study.Perioperative medicine (London, England) · 2021Article
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis article describes the methods and results of the early part (experimental pain tests and postoperative analgesia) of a study that assesses genetic and other factors related to acute pain and persistent pain after treatment of breast cancer in a prospective cohort of 1,000 women.
methodsOne thousand consenting patients were recruited to the study. Before surgery (breast resection or mastectomy with axillary surgery), the patients filled in questionnaires about health, life style, depression (Beck Depression Inventory), and anxiety (State-Trait Anxiety Inventory). They were also exposed to experimental tests measuring heat (43° and 48°C, 5 s) and cold (2-4°C) pain intensity and tolerance. Anesthesia was standardized with propofol and remifentanil, and postoperative analgesia was optimized with i.v. oxycodone.
resultsThe patients showed significant interindividual variation in heat and cold pain sensitivity and cold pain tolerance. There was a strong correlation between the experimental pain measures across the tests. Presence of chronic pain, the number of previous operations, and particularly state anxiety were related to increased pain sensitivity. Previous smoking correlated with decreased heat pain sensitivity. These factors explained 4-5% of the total variance in pain sensitivity in these tests. Oxycodone consumption during 20 h was significantly higher in patients who had axillary clearance. Oxycodone consumption had only a weak correlation with the experimental pain measures.
conclusionsContact heat and cold pressure tests identify variability in pain sensitivity which is modified by factors such as anxiety, chronic pain, previous surgery, and smoking. High levels of anxiety are connected to increased pain sensitivity in experimental and acute postoperative pain.
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