ArticleScientific reports2013
Active and secreted IgA-coated bacterial fractions from the human gut reveal an under-represented microbiota core.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Residents or Tourists: Is the Lactating Mammary Gland Colonized by Residential Microbiota?Microorganisms · 2024Review
- Intestinal IgA-Coated Bacteria in Healthy- and Altered-Microbiomes (Dysbiosis) and Predictive Value in Successful Fecal Microbiota Transplantation.Microorganisms · 2022Review
- Oral Vaccination Using a Probiotic Vaccine Platform Combined with Prebiotics Impacts Immune Response and the Microbiome.Vaccines · 2022Article
- Shared and Non-Shared sIgA-Coated and -Uncoated Bacteria in Intestine of Mother-Infant Pairs.International journal of molecular sciences · 2022Article
- Profile of the Gut Microbiome Containing Carbapenem-Resistant Enterobacteriaceae in ICU Patients.Microorganisms · 2022Article
- Gut Microbiome and Neuroinflammation in Hypertension.Circulation research · 2022Review
- Population dynamics ofFrontiers in microbiology · 2022Article
- Roles of Secretory Immunoglobulin A in Host-Microbiota Interactions in the Gut Ecosystem.Frontiers in microbiology · 2022Review
- Perturbed Microbiota/Immune Homeostasis in Multiple Sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2021Article
- Secretory IgA in Intestinal Mucosal Secretions as an Adaptive Barrier against Microbial Cells.International journal of molecular sciences · 2020Review
- Canola meal in nursery pig diets: growth performance and gut health.Journal of animal science · 2020Article
- Human IgA binds a diverse array of commensal bacteria.The Journal of experimental medicine · 2020Article
- Human milk microbiota associated with early colonization of the neonatal gut in Mexican newborns.PeerJ · 2020Article
- The antibody/microbiota interface in health and disease.Mucosal immunology · 2020Review
- Towards the Oral Treatment of Ileo-Colonic Inflammatory Bowel Disease with Infliximab Tablets: Development and Validation of the Production Process.Pharmaceutics · 2019Article
- Mining the microbiota for microbial and metabolite-based immunotherapies.Nature reviews. Immunology · 2019Review
- Host immunoglobulin G selectively identifies pathobionts in pediatric inflammatory bowel diseases.Microbiome · 2019Article
- Article
- Free Total Rhubarb Anthraquinones Protect Intestinal Injury via Regulation of the Intestinal Immune Response in a Rat Model of Severe Acute Pancreatitis.Frontiers in pharmacology · 2018Article
- Modulation of the immune system by the gut microbiota in the development of type 1 diabetes.Human vaccines & immunotherapeutics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Host-associated microbiota varies in distribution depending on the body area inhabited. Gut microbes are known to interact with the human immune system, maintaining gut homoeostasis. Thus, we studied whether secreted-IgA (S-IgA) coat specific microbial taxa without inducing strong immune responses. To do so, we fractionated gut microbiota by flow cytometry. We found that active and S-IgA-coated bacterial fractions were characterized by a higher diversity than those observed in raw faecal suspensions. A long-tail effect was observed in family distribution, revealing that rare bacteria represent up to 20% of total diversity. While Firmicutes was the most abundant phylum, the majority of its sequences were not assigned at the genus level. Finally, the single-cell-based approach enabled us to focus on active and S-IgA-coated bacteria. Thus, we revealed a microbiota core common to the healthy volunteers participating in the study. Interestingly, this core was composed mainly of low frequency taxa (e.g. Sphingomonadaceae).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.