Evidence map›Paper›PMID 24342924›Full record

ArticleBiological psychiatry2014

Neuropeptide Y receptor gene expression in the primate amygdala predicts anxious temperament and brain metabolism.

Patrick H Roseboom, Steven A Nanda, Andrew S Fox, Jonathan A Oler, Alexander J Shackman, Steven E Shelton, Richard J Davidson, Ned H Kalin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Rare protein-disrupting variants inmedRxiv : the preprint server for health sciences · 2026
    Article
  3. Review
  4. Translation of monosynaptic circuits underlying amygdala fMRI neurofeedback training.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Mechanisms underlying the early risk to develop anxiety and depression: A translational approach.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2017
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Emerging drugs for the treatment of anxiety.Expert opinion on emerging drugs · 2015
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Patrick H RoseboomDepartment of Psychiatry , University of Wisconsin at Madison, Madison, Wisconsin; HealthEmotions Research Institute, University of Wisconsin at Madison, Madison, Wisconsin. Electronic address: roseboom@wisc.edu.
Steven A NandaDepartment of Psychiatry , University of Wisconsin at Madison, Madison, Wisconsin; HealthEmotions Research Institute, University of Wisconsin at Madison, Madison, Wisconsin.
Andrew S FoxDepartment of Psychiatry , University of Wisconsin at Madison, Madison, Wisconsin; Department of Psychology, University of Wisconsin at Madison, Madison, Wisconsin; Center for Investigating Healthy Minds, University of Wisconsin at Madison, Madison, Wisconsin; HealthEmotions Research Institute, University of Wisconsin at Madison, Madison, Wisconsin; Lane Neuroimaging Laboratory, University of Wisconsin at Madison, Madison, Wisconsins; Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin at Madison, Madison, Wisconsin.
Jonathan A OlerDepartment of Psychiatry , University of Wisconsin at Madison, Madison, Wisconsin; HealthEmotions Research Institute, University of Wisconsin at Madison, Madison, Wisconsin; Lane Neuroimaging Laboratory, University of Wisconsin at Madison, Madison, Wisconsins.
Alexander J ShackmanDepartment of Psychology, Maryland Neuroimaging Center and the Neuroscience and Cognitive Science Program, University of Maryland, College Park, Maryland.
Steven E SheltonDepartment of Psychiatry , University of Wisconsin at Madison, Madison, Wisconsin; HealthEmotions Research Institute, University of Wisconsin at Madison, Madison, Wisconsin.
Richard J DavidsonDepartment of Psychiatry , University of Wisconsin at Madison, Madison, Wisconsin; Department of Psychology, University of Wisconsin at Madison, Madison, Wisconsin; Center for Investigating Healthy Minds, University of Wisconsin at Madison, Madison, Wisconsin; HealthEmotions Research Institute, University of Wisconsin at Madison, Madison, Wisconsin; Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin at Madison, Madison, Wisconsin.
Ned H KalinDepartment of Psychiatry , University of Wisconsin at Madison, Madison, Wisconsin; Department of Psychology, University of Wisconsin at Madison, Madison, Wisconsin; Center for Investigating Healthy Minds, University of Wisconsin at Madison, Madison, Wisconsin; HealthEmotions Research Institute, University of Wisconsin at Madison, Madison, Wisconsin; Lane Neuroimaging Laboratory, University of Wisconsin at Madison, Madison, Wisconsins.
University of Wisconsin–Madison · USUniversity of Maryland, College Park · US

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
ZOLEDRONATE PREVENTS BONE LOSS IN OVARIECTOMIZED RHESUS MONKEYSP51RR000167 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI WATKINS, DAVID I · 1985 to 2011
$106.7M
WISCONSIN CENTER ON MENTAL RETARDATION: CORE SUPPORTP30HD003352 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI MESSING, ALBEE · 1985 to 2015
$25.2M
DEVELOPMENT AND REGULATION OF EMOTION IN PRIMATESR01MH046729 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI Ned H Kalin · 1990 to 2026
$15.3M
Brain Mechanisms Mediating Genetic Risk For Anxiety And DepressionR01MH081884 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI Ned H Kalin · 2008 to 2026
$14.8M
TRAINING PROGRAM IN EMOTION RESEARCHT32MH018931 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI Richard J Davidson · 1989 to 2026
$11.6M
Summer Research ExperienceP50MH100031 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI KALIN, NED H · 2013 to 2017
$10.4M
STRESS EXPOSURE, HPA ACTIVITY AND RISK FOR ADOLESCENT INTERNALIZING DISORDERSP50MH084051 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI GOLDSMITH, HAROLD HILL · 2008 to 2012
$9.6M
Combining mouse and monkey models to understand human risk for psychopathologyR21MH091550 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI KALIN, NED H · 2011 to 2012
$408k
NCRR NIH HHS P51 RR000167NCRR NIH HHS P51RR000167NICHD NIH HHS P30 HD003352NICHD NIH HHS P30HD003352NIH HHS P51 OD011106NIH HHS P51OD011106NIMH NIH HHS MH018931NIMH NIH HHS P50 MH084051NIMH NIH HHS P50 MH100031NIMH NIH HHS P50MH84051NIMH NIH HHS R01 MH046729NIMH NIH HHS R01 MH081884NIMH NIH HHS R01MH46729NIMH NIH HHS R01MH81884NIMH NIH HHS R21 MH091550NIMH NIH HHS R21MH91550NIMH NIH HHS T32 MH018931
6 · The paper itself

Abstract

backgroundAnxious temperament (AT) is identifiable early in life and predicts the later development of anxiety disorders and depression. Neuropeptide Y (NPY) is a putative endogenous anxiolytic neurotransmitter that adaptively regulates responses to stress and might confer resilience to stress-related psychopathology. With a well-validated nonhuman primate model of AT, we examined expression of the NPY system in the central nucleus (Ce) of the amygdala, a critical neural substrate for extreme anxiety.

methodsIn 24 young rhesus monkeys, we measured Ce messenger RNA (mRNA) levels of all members of the NPY system that are detectable in the Ce with quantitative real time polymerase chain reaction. We then examined the relationship between these mRNA levels and both AT expression and brain metabolism.

resultsLower mRNA levels of neuropeptide Y receptor 1 (NPY1R) and NPY5R but not NPY or NPY2R in the Ce predicted elevated AT; mRNA levels for NPY1R and NPY5R in the motor cortex were not related to AT. In situ hybridization analysis provided for the first time a detailed description of NPY1R and NPY5R mRNA distribution in the rhesus amygdala and associated regions. Lastly, mRNA levels for these two receptors in the Ce predicted metabolic activity in several regions that have the capacity to regulate the Ce.

conclusionsDecreased NPY signaling in the Ce might contribute to the altered metabolic activity that is a component of the neural substrate underlying AT. This suggests that enhancement of NPY signaling might reduce the risk to develop psychopathology.

Indexed as

AnimalsAnxietyBrainCentral Amygdaloid NucleusGene ExpressionMacaca mulattaReceptors, Neuropeptide YRNA, Messengerneuropeptide Y2 receptorneuropeptide Y5 receptorneuropeptide Y-Y1 receptorReceptors, Neuropeptide YRNA, MessengerAnxietybehavioral inhibitiondepressionprefrontal cortexrhesus macaquestress

Identifiers

PMID24342924
PMCPMC4022724
OpenAlexW1990976882

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.