ArticleUltrasound in medicine & biology2014
Synthesis and characterization of transiently stable albumin-coated microbubbles via a flow-focusing microfluidic device.
Article in Ultrasound in medicine & biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Optical and Acoustic Characterization of Phase-Shift Droplets with Varying Shell Compositions.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Targeted Microbubbles for Drug, Gene, and Cell Delivery in Therapy and Immunotherapy.Pharmaceutics · 2023Review
- Characterization of the interaction of nanobubble ultrasound contrast agents with human blood components.Bioactive materials · 2023Article
- Generating Lifetime-Enhanced Microbubbles by Decorating Shells with Silicon Quantum Nano-Dots Using a 3-Series T-Junction Microfluidic Device.Langmuir : the ACS journal of surfaces and colloids · 2022Article
- Microbubbles Stabilized by Protein Shell: From Pioneering Ultrasound Contrast Agents to Advanced Theranostic Systems.Pharmaceutics · 2022Review
- Article
- Efficacy of Sonothrombolysis Using Microbubbles Produced by a Catheter-Based Microfluidic Device in a Rat Model of Ischemic Stroke.Annals of biomedical engineering · 2019Article
- Micropipette-Based Microfluidic Device for Monodisperse Microbubbles Generation.Micromachines · 2018Article
- In Vitro Sonothrombolysis Enhancement by Transiently Stable Microbubbles Produced by a Flow-Focusing Microfluidic Device.Annals of biomedical engineering · 2018Article
- Microbubbles used for contrast enhanced ultrasound and theragnosis: a review of principles to applications.Biomedical engineering letters · 2017Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
We describe a method for synthesizing albumin-shelled, large-diameter (>10 μm), transiently stable microbubbles using a flow-focusing microfluidic device (FFMD). The microfluidic device enables microbubbles to be produced immediately before insonation, thus relaxing the requirements for stability. Both reconstituted fractionated bovine serum albumin (BSA) and fresh bovine blood plasma were investigated as shell stabilizers. Microbubble coalescence was inhibited by the addition of either dextrose or glycerol and propylene glycol. Microbubbles were observed to have an acoustic half-life of approximately 6 s. Microbubbles generated directly within a vessel phantom containing flowing blood produced a 6.5-dB increase in acoustic signal within the lumen. Microbubbles generated in real time upstream of in vitro rat aortic smooth muscle cells under physiologic flow conditions successfully permeabilized 58% of the cells on insonation at a peak negative pressure of 200 kPa. These results indicate that transiently stable microbubbles produced via flow-focusing microfluidic devices are capable of image enhancement and drug delivery. In addition, successful microbubble production with blood plasma suggests the potential to use blood as a stabilizing shell.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.