ArticleBiomaterials2014
Optical imaging of fibrin deposition to elucidate participation of mast cells in foreign body responses.
Article in Biomaterials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Serum tryptase and IgE before and after explantation in women with breast implant illness.JPRAS open · 2026Article
- A spatiotemporal selective bioinspired hybrid system engineered for preventing post-thrombolysis recurrence by inhibiting the ferroptosis pathway and reprogramming macrophages.Acta pharmaceutica Sinica. B · 2026Article
- Heterogeneous vascular response after implantation of bare nitinol self-expanding stents in the swine femoropopliteal artery.Cardiovascular intervention and therapeutics · 2023Article
- Regulation of biomaterial implantation-induced fibrin deposition to immunological functions of dendritic cells.Materials today. Bio · 2022Article
- Mast Cell-Biomaterial Interactions and Tissue Repair.Tissue engineering. Part B, Reviews · 2021Review
- Non-invasive in vivo monitoring of transplanted stem cells in 3D-bioprinted constructs using near-infrared fluorescent imaging.Bioengineering & translational medicine · 2021Article
- Imaging in Chronic Wound Diagnostics.Advances in wound care · 2020Review
- Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics.Nature reviews. Neuroscience · 2018Review
- An optical probe for detecting chondrocyte apoptosis in response to mechanical injury.Scientific reports · 2017Article
- Fibrinolytic Enzyme Cotherapy Improves Tumor Perfusion and Therapeutic Efficacy of Anticancer Nanomedicine.Cancer research · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Mast cell activation has been shown to be an initiator and a key determinant of foreign body reactions. However, there is no non-invasive method that can quantify the degree of implant-associated mast cell activation. Taking advantage of the fact that fibrin deposition is a hallmark of mast cell activation around biomaterial implants, a near infrared probe was fabricated to have high affinity to fibrin. Subsequent in vitro testing confirmed that this probe has high affinity to fibrin. Using a subcutaneous particle implantation model, we found significant accumulation of fibrin-affinity probes at the implant sites as early as 15 min following particle implantation. The accumulation of fibrin-affinity probes at the implantation sites could also be substantially reduced if anti-coagulant - heparin was administered at the implant sites. Further studies have shown that subcutaneous administration of mast cell activator - compound 48/80 - prompted the accumulation of fibrin-affinity probes. However, implant-associated fibrin-affinity probe accumulation was substantially reduced in mice with mast cell deficiency. The results show that our fibrin-affinity probes may serve as a powerful tool to monitor and measure the extent of biomaterial-mediated fibrin deposition and mast cell activation in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.