ArticleAntimicrobial agents and chemotherapy2014
Trends in antibiotic resistance in coagulase-negative staphylococci in the United States, 1999 to 2012.
Article in Antimicrobial agents and chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 108 citations in OpenAlex.
- Empirical antibiotics targeting gram-positive bacteria for the treatment of febrile neutropenic patients with cancer.The Cochrane database of systematic reviews · 2017Pooled it
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- Prevalence and antimicrobial resistance of gram-positive pathogens in Lebanon: The need for surveillance and stewardship.New microbes and new infections · 2025Article
- Rapid antimicrobial susceptibility tests performed by self-diluting microfluidic chips for drug resistance studies and point-of-care diagnostics.Microsystems & nanoengineering · 2025Article
- Clinical and epidemiological differences in staphylococcal osteoarticular infections: insights for developing hospital-based infection control interventions.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Article
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- Epidemiology and drug resistance analysis of bloodstream infections in an intensive care unit from a children's medical center in Eastern China for six consecutive years.International microbiology : the official journal of the Spanish Society for Microbiology · 2024Article
- Difficult-to-Treat Pathogens: A Review on the Management of Multidrug-ResistantLife (Basel, Switzerland) · 2023Review
- Leaky barriers to gene sharing between locally co-existing coagulase-negative Staphylococcus species.Communications biology · 2023Article
- Analysis of the Presence of the Virulence and Regulation Genes fromInternational journal of environmental research and public health · 2023Article
- Therapeutic Options and Outcomes for the Treatment of Children with Gram-Positive Bacteria with Resistances of Concern: A Systematic Review.Antibiotics (Basel, Switzerland) · 2023Review
- Effect of Antibiotic Exposure onInternational journal of molecular sciences · 2023Article
- Estimating antibiotic coverage from linked microbiological and clinical data from the Swiss Paediatric Sepsis Study to support empiric antibiotic regimen selection.Frontiers in pediatrics · 2023Article
- Trends in coagulase-negative staphylococci (CoNS), England, 2010-2021.Access microbiology · 2023Article
- Variation in bacterial pneumonia diagnoses and outcomes among children hospitalized with lower respiratory tract infections.Journal of hospital medicine · 2022Article
- Multidrug-Resistant and Virulent Organisms Trauma Infections: Trauma Infectious Disease Outcomes Study Initiative.Military medicine · 2022Review
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- Distribution and Clonal Diversity ofAntibiotics (Basel, Switzerland) · 2021Article
- Extensive Horizontal Gene Transfer within and between Species of Coagulase-Negative Staphylococcus.Genome biology and evolution · 2021Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Coagulase-negative staphylococci (CoNS) are important bloodstream pathogens that are typically resistant to multiple antibiotics. Despite the concern about increasing resistance, there have been no recent studies describing the national prevalence of CoNS pathogens. We used national resistance data over a period of 13 years (1999 to 2012) from The Surveillance Network (TSN) to determine the prevalence of and assess the trends in resistance for Staphylococcus epidermidis, the most common CoNS pathogen, and all other CoNS pathogens. Over the course of the study period, S. epidermidis resistance to ciprofloxacin and clindamycin increased steadily from 58.3% to 68.4% and from 43.4% to 48.5%, respectively. Resistance to levofloxacin increased rapidly from 57.1% in 1999 to a high of 78.6% in 2005, followed by a decrease to 68.1% in 2012. Multidrug resistance for CoNS followed a similar pattern, and this rise and small decline in resistance were found to be strongly correlated with levofloxacin prescribing patterns. The resistance patterns were similar for the aggregate of CoNS pathogens. The results from our study demonstrate that the antibiotic resistance in CoNS pathogens has increased significantly over the past 13 years. These results are important, as CoNS can serve as sentinels for monitoring resistance, and they play a role as reservoirs of resistance genes that can be transmitted to other pathogens. The link between the levofloxacin prescription rate and resistance levels suggests a critical role for reducing the inappropriate use of fluoroquinolones and other broad-spectrum antibiotics in health care settings and in the community to help curb the reservoir of resistance in these colonizing pathogens.
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