Evidence map›Paper›PMID 24342580›Full record

ArticleJournal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons2014

Amifostine preserves osteocyte number and osteoid formation in fracture healing following radiotherapy.

Alexis Donneys, Catherine N Tchanque-Fossuo, Jordan T Blough, Noah S Nelson, Sagar S Deshpande, Steven R Buchman

Abstract read
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In one paragraph

Article in Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Alexis DonneysResearch Fellow, Craniofacial Research Laboratory, Plastic Surgery Section, University of Michigan, Ann Arbor, MI.
Catherine N Tchanque-FossuoResearch Fellow, Craniofacial Research Laboratory, Plastic Surgery Section, University of Michigan, Ann Arbor, MI.
Jordan T BloughResearch Assistant, Craniofacial Research Laboratory, Plastic Surgery Section, University of Michigan, Ann Arbor, MI.
Noah S NelsonResearch Fellow, Craniofacial Research Laboratory, Plastic Surgery Section, University of Michigan, Ann Arbor, MI.
Sagar S DeshpandeResearch Fellow, Craniofacial Research Laboratory, Plastic Surgery Section, University of Michigan, Ann Arbor, MI.
Steven R BuchmanM. Haskell Newman Collegiate Professor of Plastic Surgery, Professor of Surgery, and Professor of Neurosurgery, Craniofacial Research Laboratory, Plastic Surgery Section, University of Michigan, Ann Arbor, MI. Electronic address: sbuchman@med.umich.edu.
University of Michigan–Ann Arbor · US

Funding

TRAINING GRANT IN TRAUMA, BURN AND WOUND HEALING RESEARCT32GM008616 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BUCHMAN, STEVEN R, CHUNG, KEVIN C · 1997 to 2025
$3.1M
Translational Optimization of Bone Regeneration in the Irradiated MandibleR01CA125187 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BUCHMAN, STEVEN R · 2007 to 2017
$2.8M
NCI NIH HHS R01 CA125187NIGMS NIH HHS T32 GM008616
6 · The paper itself

Abstract

purposeRadiation is known to decrease osteocyte count and function, leading to bone weakening. A treatment strategy to mitigate these consequences could have immense therapeutic ramifications. The authors previously reported significantly decreased osteocyte count and mineralization capacity in a rat model of fracture healing after radiotherapy. They hypothesized that amifostine (AMF) would preserve osteocyte number and function in this model. MATERIALS AND

methodsThirty-six rats were divided into 3 groups: fracture, radiated fracture, and radiated fracture with AMF. Radiated groups underwent human-equivalent radiotherapy to the mandible before fixator placement and mandibular osteotomy. The AMF group received a subcutaneous injection before each dose of radiotherapy. After 40 days, mandibles were harvested for histologic processing. Quantification of osteocyte count (Oc), empty lacunae (EL), and osteoid ratio (osteoid volume [OV] to tissue volume [TV]) was performed and the results were compared using analysis of variance (P < .05).

resultsRadiated fractures showed significantly decreased Oc, increased EL, and a decreased capacity to produce new osteoid at the fracture site as measured with OV/TV compared with nonradiated fractures. In mandibles treated with AMF, these metrics were not statistically different than the control, indicating a preservation of osteocyte number and function.

conclusionsThese results support the hypothesis that AMF preserves osteocyte number and function, thereby preventing the pernicious effects of radiotherapy on the cellular environment of fracture healing. Based on these findings, the authors encourage future investigation of this promising therapy for use in the prevention of pathologic fractures and osteoradionecrosis.

Indexed as

AmifostineAnimalsBone RegenerationCalcification, PhysiologicCell CountFracture HealingMaleMandibular OsteotomyOsteocytesRadiation-Protective AgentsRadiotherapyRatsRats, Sprague-DawleyAmifostineRadiation-Protective Agents

Identifiers

PMID24342580
PMCPMC3944920
OpenAlexW2089322787

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.