Evidence map›Paper›PMID 24342069›Full record

ArticleJournal of vascular surgery2014

Flow reversal promotes intimal thickening in vein grafts.

Yong He, Chessy M Fernandez, Zhihua Jiang, Ming Tao, Kerri A O'Malley, Scott A Berceli

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of vascular surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Association of Shear Stress with Subsequent Lumen Remodeling in Hemodialysis Arteriovenous Fistulas.Clinical journal of the American Society of Nephrology : CJASN · 2023
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yong HeMalcom Randall VAMC, Gainesville, Fla; Division of Vascular Surgery and Endovascular Therapy, Department of Surgery, College of Medicine, University of Florida, Gainesville, Fla.
Chessy M FernandezMalcom Randall VAMC, Gainesville, Fla; Department of Biomedical Engineering, College of Engineering, University of Florida, Gainesville, Fla.
Zhihua JiangMalcom Randall VAMC, Gainesville, Fla; Division of Vascular Surgery and Endovascular Therapy, Department of Surgery, College of Medicine, University of Florida, Gainesville, Fla.
Ming TaoMalcom Randall VAMC, Gainesville, Fla; Division of Vascular Surgery and Endovascular Therapy, Department of Surgery, College of Medicine, University of Florida, Gainesville, Fla.
Kerri A O'MalleyMalcom Randall VAMC, Gainesville, Fla; Division of Vascular Surgery and Endovascular Therapy, Department of Surgery, College of Medicine, University of Florida, Gainesville, Fla.
Scott A BerceliMalcom Randall VAMC, Gainesville, Fla; Division of Vascular Surgery and Endovascular Therapy, Department of Surgery, College of Medicine, University of Florida, Gainesville, Fla. Electronic address: bercesa@surgery.ufl.edu.
Malcom Randall VA Medical Center · USUniversity of Florida · US

Funding

Constitutive and Agent-Based Multiscale Models to Improve Vein Graft SurvivalU01HL119178 · NHLBI · UNIVERSITY OF FLORIDA · PI BERCELI, SCOTT A, GARBEY, MARC · 2013 to 2018
$2.7M
The Dichotomy of Alk1 and Alk5 Signaling Pathways in Vascular Response to InjuryR01HL105764 · NHLBI · UNIVERSITY OF FLORIDA · PI JIANG, ZHIHUA · 2011 to 2015
$1.6M
Multiscale Network Modeling of Hemodynamically-Driven Vascular AdaptationR01HL095508 · NHLBI · UNIVERSITY OF FLORIDA · PI BERCELI, SCOTT A · 2009 to 2012
$1.5M
NHLBI NIH HHS 5R01-HL095508NHLBI NIH HHS R01 HL095508NHLBI NIH HHS R01 HL105764NHLBI NIH HHS U01 HL119178
6 · The paper itself

Abstract

objectiveAfter vascular interventions, unidentified mechanisms disrupt the homeostasis of a focal narrowing to initiate an intimal thickening response. We hypothesize that perturbations in the hemodynamic microenvironment are the initiating event for this disruption of homeostasis and intimal thickening in vein bypass grafts. The objective of this study was to investigate the relation between local flow perturbations and its influence on the vein graft architecture.

methodsAn external ligature was used to create an 80% focal midgraft stenosis in bilateral rabbit carotid vein grafts. A unilateral distal ligation created a ninefold difference in flow rate between high-flow and low-flow grafts. Ten vein grafts were harvested at 28 days and serially sectioned for morphologic evaluation and vein graft reconstruction. Computational fluid dynamics analyses were performed to examine the hemodynamic environment within these complex flow regions.

resultsThe largest intimal thickening occurred exclusively within the region immediately distal to the maximum stenosis in high-flow grafts, which was characterized by persistent flow separation and reversal for the entire cardiac cycle. In regions of low to moderate shear stress (<5 Pa), the typical inverse correlation between intimal thickness and wall shear was observed.

conclusionsRegions of vein bypass grafts exposed to persistent flow reversal are most at risk for intimal thickening and loss of lumen.

Indexed as

NeointimaAnimalsCarotid Artery, CommonComputer SimulationConstriction, PathologicDisease Models, AnimalGraft Occlusion, VascularHemodynamicsHydrodynamicsJugular VeinsMaleModels, CardiovascularRabbitsRegional Blood FlowTime Factors

Identifiers

PMID24342069
PMCPMC4087076
OpenAlexW2158522636

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.