ArticleRespiratory physiology & neurobiology2014
Rapid diaphragm atrophy following cervical spinal cord hemisection.
Article in Respiratory physiology & neurobiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Outcomes in critically ill patients after diaphragmatic stimulation on ventilator-induced diaphragmatic dysfunction: a systematic review.European journal of physical and rehabilitation medicine · 2023Pooled it
- Antioxidant Upregulation Contributes to Improvements in Diaphragm Function Following Cervical Spinal Cord Injury and Hyperbaric Oxygen Therapy.Antioxidants (Basel, Switzerland) · 2026Article
- Sepsis Dysregulates Mitochondrial microRNA and Biogenesis in the Diaphragm but Not Limb Muscle.International journal of molecular sciences · 2026Article
- Small-Molecule Targeting MuRF1 Protects Against Denervation-Induced Diaphragmatic Dysfunction: Underlying Molecular Mechanisms.Journal of cachexia, sarcopenia and muscle · 2025Article
- An update on spinal cord injury and diaphragm neuromotor control.Expert review of respiratory medicine · 2025Review
- Sex differences in spontaneous respiratory recovery following chronic C2 hemisection.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Changes in respiratory structure and function after traumatic cervical spinal cord injury: observations from spinal cord and brain.Frontiers in neurology · 2023Review
- Respiratory plasticity following spinal cord injury: perspectives from mouse to man.Neural regeneration research · 2022Review
- Oxygen transport kinetics underpin rapid and robust diaphragm recovery following chronic spinal cord injury.The Journal of physiology · 2021Article
- Effects of aerobic exercise training on muscle plasticity in a mouse model of cervical spinal cord injury.Scientific reports · 2021Article
- Pharmacological disinhibition enhances paced breathing following complete spinal cord injury in rats.Respiratory physiology & neurobiology · 2020Article
- Hyperbaric Oxygen Treatment Following Mid-Cervical Spinal Cord Injury Preserves Diaphragm Muscle Function.International journal of molecular sciences · 2020Article
- Protein Degradome of Spinal Cord Injury: Biomarkers and Potential Therapeutic Targets.Molecular neurobiology · 2020Review
- Spinal cord injury and diaphragm neuromotor control.Expert review of respiratory medicine · 2020Review
- Rapid and robust restoration of breathing long after spinal cord injury.Nature communications · 2018Article
- Mid-cervical spinal cord contusion causes robust deficits in respiratory parameters and pattern variability.Experimental neurology · 2018Article
- Anatomical Recruitment of Spinal V2a Interneurons into Phrenic Motor Circuitry after High Cervical Spinal Cord Injury.Journal of neurotrauma · 2017Article
- The crossed phrenic phenomenon.Neural regeneration research · 2017Review
- Functional recovery after cervical spinal cord injury: Role of neurotrophin and glutamatergic signaling in phrenic motoneurons.Respiratory physiology & neurobiology · 2016Review
- Forelimb muscle plasticity following unilateral cervical spinal cord injury.Muscle & nerve · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
A cervical (C2) hemilesion (C2Hx), which disrupts ipsilateral bulbospinal inputs to the phrenic nucleus, was used to study diaphragm plasticity after acute spinal cord injury. We hypothesized that C2Hx would result in rapid atrophy of the ipsilateral hemidiaphragm and increases in mRNA expression of proteolytic biomarkers. Diaphragm tissue was harvested from male Sprague-Dawley rats at 1 or 7 days following C2Hx. Histological analysis demonstrated reduction in cross-sectional area (CSA) of type I and IIa fibers in the ipsilateral hemidiaphragm at 1 but not 7 days. Type IIb/x fibers, however, had reduced CSA at 1 and 7 days. A targeted gene array was used to screen mRNA changes for genes associated with skeletal muscle myopathy and myogenesis; this was followed by qRT-PCR validation. Changes in diaphragm gene expression suggested that profound myoplasticity is initiated immediately following C2Hx including activation of both proteolytic and myogenic pathways. We conclude that an immediate myoplastic response occurs in the diaphragm after C2Hx with atrophy occurring in ipsilateral myofibers within 1 day.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.