ArticleAddiction biology2015
Increased impulsivity in rats as a result of repeated cycles of alcohol intoxication and abstinence.
Article in Addiction biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 47 citations in OpenAlex.
- Sex and Genetic Differences in Behavioral Engagement of Crossed High Alcohol-Preferring and Low Alcohol-Preferring Mice.Genes, brain, and behavior · 2025Article
- Cognitive Dysfunction in the Addictions (CDiA): protocol for a neuron-to-neighbourhood collaborative research program.Frontiers in psychiatry · 2025Article
- Aberrant glutamatergic systems underlying impulsive behaviors: Insights from clinical and preclinical research.Progress in neuro-psychopharmacology & biological psychiatry · 2024Review
- Engagement for alcohol escalates in the 5-choice serial reaction time task after intermittent access.Alcohol (Fayetteville, N.Y.) · 2024Article
- Cognitive Alterations in Addictive Disorders: A Translational Approach.Biomedicines · 2023Review
- The effects of acamprosate on prefrontal cortical function are mimicked by CaCl2 and they are influenced by the history of alcohol exposure.Neuropharmacology · 2022Article
- Maternal Separation Alters Ethanol Drinking and Reversal Learning Processes in Adolescent Rats: The Impact of Sex and Glycine Transporter Type 1 (GlyT1) Inhibitor.International journal of molecular sciences · 2022Article
- Cognitive performance during adulthood in a rat model of neonatal diffuse white matter injury.Psychopharmacology · 2022Article
- Adaptation of the 5-choice serial reaction time task to measure engagement and motivation for alcohol in mice.Frontiers in behavioral neuroscience · 2022Article
- Ethanol induces maladaptive impulse control and decreased seeking behaviors in mice.Addiction biology · 2020Article
- Article
- Recruitment and disruption of ventral pallidal cue encoding during alcohol seeking.The European journal of neuroscience · 2019Article
- The monoamine stabilizer (-)-OSU6162 prevents the alcohol deprivation effect and improves motor impulsive behavior in rats.Addiction biology · 2019Article
- A Working Hypothesis for the Role of the Cerebellum in Impulsivity and Compulsivity.Frontiers in behavioral neuroscience · 2019Article
- Defining the place of habit in substance use disorders.Progress in neuro-psychopharmacology & biological psychiatry · 2018Review
- Operant over-responding is more sensitive than reversal learning for revealing behavioral changes after withdrawal from alcohol consumption.Physiology & behavior · 2018Article
- Phosphorylation of calcium/calmodulin-dependent protein kinase II in the rat dorsal medial prefrontal cortex is associated with alcohol-induced cognitive inflexibility.Addiction biology · 2018Article
- Ethanol Reinforcement Elicits Novel Response Inhibition Behavior in a Rat Model of Ethanol Dependence.Brain sciences · 2018Article
- Morphological and functional evidence of increased excitatory signaling in the prelimbic cortex during ethanol withdrawal.Neuropharmacology · 2018Article
- Adolescents show differential dysfunctions related to Alcohol and Cannabis Use Disorder severity in emotion and executive attention neuro-circuitries.NeuroImage. Clinical · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Impulsivity is a risk factor for alcoholism, and long-term alcohol exposure may further impair impulse control in a manner that propels problematic alcohol use. The present study employed the rat 5-choice serial reaction time task (5-CSRTT) to measure behavioral inhibition and attentional capacity during abstinence from repeated 5-day cycles of alcohol liquid diet consumption. Task performance was not disrupted following the first cycle of alcohol exposure; however, evidence of impaired behavioral inhibition emerged following the third cycle of alcohol exposure. In comparison with controls, alcoholic rats exhibited deficits in inhibitory control during cognitively challenging 5-CSRTT tests employing variable intertrial interval (varITI). This behavioral disruption was not present during early abstinence (3 days) but was evident by 7 days of abstinence and persisted for at least 34 days. Interestingly, renewed alcohol consumption ameliorated these disruptions in impulse control, although deficient behavioral inhibition re-emerged during subsequent abstinence. Indices of increased impulsivity were no longer present in tests conducted after 49 days of abstinence. Alcohol-related impairments in impulse control were not evident in sessions employing highly familiar task parameters regardless of the abstinence period, and control experiments confirmed that performance deficits during the challenge sessions were unlikely to result from alcohol-related disruption in the adaptation to repeated varITI testing. Together, the current findings demonstrate that chronic intermittent alcohol consumption results in decreased behavioral inhibition in rats that is temporally similar to clinical observations of disrupted impulsive control in abstinent alcoholics performing tasks of behavioral inhibition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.