ArticleBMC genomics2013
Genome wide association studies for body conformation traits in the Chinese Holstein cattle population.
Article in BMC genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.
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Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genomic regions associated with muscularity in beef cattle differ in five contrasting cattle breeds.Genetics, selection, evolution : GSE · 2020Pooled it
- Genomic dissection of hoof and leg conformation in Swiss dairy cattle populations reveals polygenic architecture and a recessive HYAL1 nonsense variant affecting longevity in Holstein cattle.Genetics, selection, evolution : GSE · 2026Article
- Neuron-specific expression of transmembrane protein 130 (TMEM130).Scientific reports · 2026Article
- Genetic Diversification and Population Admixture Signatures in Yunnan Native Cattle.Animals : an open access journal from MDPI · 2026Article
- The Genomic Landscape of Cattle: Domestication, Dispersal, and Adaptive Evolution.Animals : an open access journal from MDPI · 2026Review
- Candidate genes related to growth and milk production in three Anatolian goats revealed by GWAS.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- Composite selection signal analysis: Uncovering candidate genes and quantitative trait loci in Indian sheep breeds.PloS one · 2026Article
- Population structure and genome-wide association study of body conformation traits of two native goat breeds in China.Animal bioscience · 2026Article
- Comparative evaluation of SNP-weighted, Bayesian, and machine learning models for genomic prediction in Holstein cattle.BMC genomics · 2025Article
- Genomic diversity in Chinese Holstein cattle and genome-wide association study for body conformation traits.BMC genomics · 2025Article
- Whole-Genome Insights into the Genetic Basis of Conformation Traits in German Black Pied (DSN) Cattle.Genes · 2025Article
- Applying the algorithm for Proven and young in GWAS Reveals high polygenicity for key traits in Nellore cattle.Frontiers in genetics · 2025Article
- Genome-wide association studies for conformation traits in the Turkish Holstein cattle population.Iranian journal of veterinary research · 2025Article
- Genome-wide association analysis of body conformation traits in Chinese Holstein Cattle.BMC genomics · 2024Article
- Combined Genome-Wide Association Study and Haplotype Analysis Identifies Candidate Genes Affecting Growth Traits of Inner Mongolian Cashmere Goats.Veterinary sciences · 2024Article
- Genome-Wide Association Study as an Efficacious Approach to Discover Candidate Genes Associated with Body Linear Type Traits in Dairy Cattle.Animals : an open access journal from MDPI · 2024Review
- Improving the accuracy of genomic prediction in dairy cattle using the biologically annotated neural networks framework.Journal of animal science and biotechnology · 2024Article
- Genome-Wide Association Study of Body Conformation Traits in Tashi Goats (Animals : an open access journal from MDPI · 2024Article
- Evaluation of accuracies of genomic predictions for body conformation traits in Korean Holstein.Animal bioscience · 2024Article
- Enhancing Genomic Prediction Accuracy for Body Conformation Traits in Korean Holstein Cattle.Animals : an open access journal from MDPI · 2024Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors.
Funding
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Abstract
backgroundGenome-wide association study (GWAS) is a powerful tool for revealing the genetic basis of quantitative traits. However, studies using GWAS for conformation traits of cattle is comparatively less. This study aims to use GWAS to find the candidates genes for body conformation traits.
resultsThe Illumina BovineSNP50 BeadChip was used to identify single nucleotide polymorphisms (SNPs) that are associated with body conformation traits. A least absolute shrinkage and selection operator (LASSO) was applied to detect multiple SNPs simultaneously for 29 body conformation traits with 1,314 Chinese Holstein cattle and 52,166 SNPs. Totally, 59 genome-wide significant SNPs associated with 26 conformation traits were detected by genome-wide association analysis; five SNPs were within previously reported QTL regions (Animal Quantitative Trait Loci (QTL) database) and 11 were very close to the reported SNPs. Twenty-two SNPs were located within annotated gene regions, while the remainder were 0.6-826 kb away from known genes. Some of the genes had clear biological functions related to conformation traits. By combining information about the previously reported QTL regions and the biological functions of the genes, we identified DARC, GAS1, MTPN, HTR2A, ZNF521, PDIA6, and TMEM130 as the most promising candidate genes for capacity and body depth, chest width, foot angle, angularity, rear leg side view, teat length, and animal size traits, respectively. We also found four SNPs that affected four pairs of traits, and the genetic correlation between each pair of traits ranged from 0.35 to 0.86, suggesting that these SNPs may have a pleiotropic effect on each pair of traits.
conclusionsA total of 59 significant SNPs associated with 26 conformation traits were identified in the Chinese Holstein population. Six promising candidate genes were suggested, and four SNPs showed genetic correlation for four pairs of traits.
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