ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2013
A twin study of genetic influences on diurnal preference and risk for alcohol use outcomes.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- The Relationship between Alcohol Craving and Insomnia Symptoms in Alcohol-Dependent Individuals.Alcohol and alcoholism (Oxford, Oxfordshire) · 2019Trial
- Article
- Youth Correlates of Genetic Liability to Substance Use Disorders.medRxiv : the preprint server for health sciences · 2025Article
- Sleep-Related Predictors of Risk for Alcohol Use and Related Problems in Adolescents and Young Adults.Alcohol research : current reviews · 2024Review
- Characterisation of the genetic relationship between the domains of sleep and circadian-related behaviours with substance use phenotypes.Addiction biology · 2022Article
- Tick-Tock Consider the Clock: The Influence of Circadian and External Cycles on Time of Day Variation in the Human Metabolome-A Review.Metabolites · 2021Review
- Article
- Evening chronotype, alcohol use disorder severity, and emotion regulation in college students.Chronobiology international · 2020Article
- Genetic Associations of Chronotype in the Finnish General Population.Journal of biological rhythms · 2020Article
- High Alcohol-Preferring Mice Show Reaction to Loss of Ethanol Reward Following Repeated Binge Drinking.Alcoholism, clinical and experimental research · 2020Article
- The genetic basis of diurnal preference in Drosophila melanogaster.BMC genomics · 2020Article
- Alcohol and sleep-related problems.Current opinion in psychology · 2019Review
- Circadian misalignment and weekend alcohol use in late adolescent drinkers: preliminary evidence.Chronobiology international · 2019Article
- The Interplay of Peer, Parent, and Adolescent Drinking.Social science quarterly · 2018Article
- Sex Differences in Photic Entrainment and Sensitivity to Ethanol-Induced Chronodisruption in Adult Mice After Adolescent Intermittent Ethanol Exposure.Alcoholism, clinical and experimental research · 2018Article
- Chronotype and Mental Health: Recent Advances.Current psychiatry reports · 2018Review
- Genetic Influences on Evening Preference Overlap with Those for Bipolar Disorder in a Sample of Mexican Americans and American Indians.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2017Article
- Differential Sensitivity to Ethanol-Induced Circadian Rhythm Disruption in Adolescent and Adult Mice.Alcoholism, clinical and experimental research · 2017Article
- Article
- Circadian Modulation of Alcohol-Induced Sedation and Recovery in Male and Female Drosophila.Journal of biological rhythms · 2016Article
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Authors and funding
3 authors.
Funding
Abstract
objectiveThe population-based University of Washington Twin Registry (UWTR) was used to examine (1) genetic influences on chronobiology and (2) whether these genetic factors influence alcohol-use phenotypes.
methodsWe used a reduced Horne-Östberg Morningness-Eveningness Questionnaire (rMEQ) to survey UWTR participants for diurnal preference. Frequency and quantity of alcohol use, as well as binge drinking (6+ drinks per occasion), were assessed on a 5-point Likert scale. Both diurnal preference and alcohol use were self-reported. Twin data were analyzed by using structural equation models.
resultsThe sample consisted of 2,945 participants (mean age = 36.4 years), including 1,127 same-sex and opposite-sex twin pairs and 691 individual twins. The rMEQ range was 4-25, with a mean score of 15.3 (SD 4.0). Diurnal "morning types" comprised 30.7% (N = 903) of participants, while 17.4% (N = 513) were "evening types." Regarding alcohol use, 21.2% (N = 624) reported never drinking. Among drinkers, 35.7% (N = 829) reported ≥ 3 drinks per occasion and 48.1% (N = 1,116) reported at least one instance of binge drinking. Genetic influences accounted for 37% of the variance in diurnal preference, with the remaining 63% due to non-shared environmental influences. Genetic propensities toward diurnal eveningness were significantly associated with increased alcohol quantity (β = -0.17; SE = 0.05, p < 0.001) and increased binge drinking (β = -0.19; SE = 0.04, p < 0.001), but not with frequency of alcohol use. Environmental paths between diurnal preference and alcohol use phenotypes were not significant.
conclusionsGenetic influences on diurnal preference confer elevated risk for problematic alcohol use, including increased quantity and binge drinking. Differences in circadian rhythm may be an important and understudied pathway of risk for genetic influences on alcohol use.
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