ArticlePLoS neglected tropical diseases2013
the intestinal expulsion of the roundworm Ascaris suum is associated with eosinophils, intra-epithelial T cells and decreased intestinal transit time.
Article in PLoS neglected tropical diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- A historical and systematic overview ofParasitology · 2021Pooled it
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- AdultCurrent research in parasitology & vector-borne diseases · 2026Article
- ConcurrentmSphere · 2024Article
- Getting around the roundworms: Identifying knowledge gaps and research priorities for the ascarids.Advances in parasitology · 2024Article
- Dietary seaweed (Saccharina latissima) supplementation in pigs induces localized immunomodulatory effects and minor gut microbiota changes during intestinal helminth infection.Scientific reports · 2023Article
- In silico design of a polypeptide as a vaccine candidate against ascariasis.Scientific reports · 2023Article
- Modulation of the porcine intestinal microbiota in the course of Ascaris suum infection.Parasites & vectors · 2022Article
- Comparison of coproprevalence and seroprevalence to guide decision-making in national soil-transmitted helminthiasis control programs: Ethiopia as a case study.PLoS neglected tropical diseases · 2022Article
- Assessing the impact of Ascariasis and Trichuriasis on weight gain using a porcine model.PLoS neglected tropical diseases · 2022Article
- The evolution of powerful yet perilous immune systems.Trends in immunology · 2022Review
- Eosinophils mediate SIgA production triggered by TLR2 and TLR4 to control Ascaris suum infection in mice.PLoS pathogens · 2021Article
- ASCVac-1, a Multi-Peptide Chimeric Vaccine, Protects Mice AgainstFrontiers in immunology · 2021Article
- Quantitative lipidomic analysis of Ascaris suum.PLoS neglected tropical diseases · 2020Article
- Whipworm and roundworm infections.Nature reviews. Disease primers · 2020Review
- Soil-Transmitted Helminth Vaccines: Are We Getting Closer?Frontiers in immunology · 2020Review
- The role of the liver in the migration of parasites of global significance.Parasites & vectors · 2019Review
- Parasite resource manipulation drives bimodal variation in infection duration.Proceedings. Biological sciences · 2019Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ascaris lumbricoides remains the most common endoparasite in humans, yet there is still very little information available about the immunological principles of protection, especially those directed against larval stages. Due to the natural host-parasite relationship, pigs infected with A. suum make an excellent model to study the mechanisms of protection against this nematode. In pigs, a self-cure reaction eliminates most larvae from the small intestine between 14 and 21 days post infection. In this study, we investigated the mucosal immune response leading to the expulsion of A. suum and the contribution of the hepato-tracheal migration. Self-cure was independent of previous passage through the liver or lungs, as infection with lung stage larvae did not impair self-cure. When animals were infected with 14-day-old intestinal larvae, the larvae were being driven distally in the small intestine around 7 days post infection but by 18 days post infection they re-inhabited the proximal part of the small intestine, indicating that more developed larvae can counter the expulsion mechanism. Self-cure was consistently associated with eosinophilia and intra-epithelial T cells in the jejunum. Furthermore, we identified increased gut movement as a possible mechanism of self-cure as the small intestinal transit time was markedly decreased at the time of expulsion of the worms. Taken together, these results shed new light on the mechanisms of self-cure that occur during A. suum infections.
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