Trial reportPloS one2013
Helicobacter pylori genomic microevolution during naturally occurring transmission between adults.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Fine-scale population structure of JapaneseMicrobial genomics · 2025Article
- Two remarkable serine/leucine polymorphisms in Helicobacter pylori: functional importance for serine protease HtrA and adhesin BabA.Cell communication and signaling : CCS · 2024Review
- Whole-genome comparison using complete genomes fromFrontiers in microbiology · 2024Article
- Genetic diversity of Helicobacter pylori type IV secretion system cagI and cagN genes and their association with clinical diseases.Scientific reports · 2023Article
- Pathogenomics of Helicobacter pylori.Current topics in microbiology and immunology · 2023Review
- Whole-Genome Sequencing and Comparative Genomics of ThreePathogens (Basel, Switzerland) · 2021Article
- Article
- Rearrangement analysis of multiple bacterial genomes.BMC bioinformatics · 2019Article
- Within-host evolution of Helicobacter pylori shaped by niche-specific adaptation, intragastric migrations and selective sweeps.Nature communications · 2019Article
- Genetic diversity and amino acid sequence polymorphism in Helicobacter pylori CagL hypervariable motif and its association with virulence markers and gastroduodenal diseases.Cancer medicine · 2019Article
- Tryptophan usage by Helicobacter pylori differs among strains.Scientific reports · 2019Article
- Genome-wide mutation analysis ofGut pathogens · 2019Article
- Article
- Occurrence of Mutations in the Antimicrobial Target Genes Related to Levofloxacin, Clarithromycin, and Amoxicillin Resistance in Helicobacter pylori Isolates from Buenos Aires City.Microbial drug resistance (Larchmont, N.Y.) · 2017Article
- Helicobacter pylori outer membrane protein and virulence marker differences in expatriate patients.Epidemiology and infection · 2016Article
- Lipopolysaccharide modification in Gram-negative bacteria during chronic infection.FEMS microbiology reviews · 2016Review
- Worldwide Population Structure, Long-Term Demography, and Local Adaptation of Helicobacter pylori.Genetics · 2015Article
- Article
- Helicobacter pylori: Genomic Insight into the Host-Pathogen Interaction.International journal of genomics · 2015Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human gastric pathogen Helicobacter pylori is usually acquired during childhood and, in the absence of treatment, chronic infection persists through most of the host's life. However, the frequency and importance of H. pylori transmission between adults is underestimated. Here we sequenced the complete genomes of H. pylori strains that were transmitted between spouses and analysed the genomic changes. Similar to H. pylori from chronic infection, a significantly high proportion of the determined 31 SNPs and 10 recombinant DNA fragments affected genes of the hop family of outer membrane proteins, some of which are known to be adhesins. In addition, changes in a fucosyltransferase gene modified the LPS component of the bacterial cell surface, suggesting strong diversifying selection. In contrast, virulence factor genes were not affected by the genomic changes. We propose a model of the genomic changes that are associated with the transmission and adaptation of H. pylori to a new human host.
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