Trial reportPloS one2013
Alcohol and smoking affect risk of uncomplicated colonic diverticulosis in Japan.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 95 citations in OpenAlex.
- Genetic, epigenetic and environmental factors in diverticular disease: systematic review.BJS open · 2024Pooled it
- Association between Alcohol Consumption and Diverticulosis and Diverticular Bleeding: A Systematic Review and Meta-analysis.Hawai'i journal of medicine & public health : a journal of Asia Pacific Medicine & Public Health · 2017Pooled it
- Trial
- Recurrence of Transverse Colon Cancer in Diverticulum 14 Years after Endoscopic Mucosal Resection: A Case Report.Surgical case reports · 2026Article
- Multiple jejunal diverticulosis, from an anatomical and histological view: A case report.World journal of gastrointestinal surgery · 2025Article
- Exploring the Diet-diverticular Disease Link: Insights from a Comprehensive Mendelian Randomization Study.Current medicinal chemistry · 2025Article
- Smoking and Alcohol Consumption and Risk of Incident Diverticulitis in Women.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2024Article
- Impact of Smoking on the Healing of Apical Periodontitis after Nonsurgical Endodontic Treatment.European journal of dentistry · 2024Article
- Active smoking in urban households: An association between urinary cotinine metabolite level and serum eGFR concentration.Tobacco induced diseases · 2024Article
- Article
- Prior abdominal surgery as a potential risk factor for colonic diverticulosis or diverticulitis.World journal of clinical cases · 2023Article
- Serotonin Metabolism and Serotonin Receptors Expression Are Altered in Colon Diverticulosis.Medicina (Kaunas, Lithuania) · 2023Article
- Increased mucosal eosinophils in colonic diverticulosis and diverticular disease.Journal of gastroenterology and hepatology · 2023Article
- Cardiovascular Risk Factors and Physical Fitness Among Subjects with Asymptomatic Colonic Diverticulosis.Digestive diseases and sciences · 2023Article
- Clinical Factors Associated with Severity of Colonic Diverticular Bleeding and Impact of Bleeding Site.Journal of clinical medicine · 2023Article
- Effectiveness of early colonoscopy in patients with colonic diverticular hemorrhage: A single-center retrospective cohort study.World journal of gastrointestinal endoscopy · 2022Article
- Analysis of TERT Rs2736100 genotype distribution in laryngeal squamous cell carcinoma patients.Journal of medicine and life · 2022Article
- Article
- Pathophysiology of Diverticular Disease: From Diverticula Formation to Symptom Generation.International journal of molecular sciences · 2022Review
- The Influence of Smoking on Renal Functions Among Apparently Healthy Smokers.Journal of multidisciplinary healthcare · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colonic diverticula are located predominantly on the right side in Asia and on the left side in Europe and the United States. Factors associated with uncomplicated colonic diverticulosis and its distribution pattern have been unknown. Our aims are to investigate the prevalence and risk factors for uncomplicated colonic diverticulosis. We conducted a prospective cross-sectional study in adults who underwent colonoscopy. Alcohol, alcohol related flushing, smoking, medications, and comorbidities were assessed by interview on the colonoscopy day. Alcohol consumption was categorized as nondrinker, light (1-180 g/week), moderate (181-360 g/week), and heavy (≥361 g/week). Smoking index was defined as the number of cigarettes per day multiplied by the number of smoking years and categorized as nonsmoker, <400, 400-799, and ≥800. A total of 2,164 consecutive patients were enrolled. Overall, 542 patients (25.1%) had uncomplicated colonic diverticulosis located on the right side (50%), bilaterally (29%), and on the left side (21%). Univariate analysis revealed age, male, smoking index, alcohol consumption, aspirin use, anticoagulants use, corticosteroid use, hypertension, and atherosclerotic disease as factors significantly associated with diverticulosis. Alcohol related flushing was not associated with the disease. Multivariate analysis showed increasing age (P<0.01), increasing alcohol consumption (P<0.01) and smoking (P<0.01), and atherosclerotic disease (P<0.01) as significantly associated factors. Alcohol and smoking were associated with right-sided and bilateral diverticula. In conclusion, one in four Japanese adults have colonic diverticulosis (50% right-sided). Age, alcohol consumption, and smoking were found to be significant risk factors for uncomplicated colonic diverticulosis, particularly right-sided and bilateral.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.