ArticlePLoS biology2013
Circadian period integrates network information through activation of the BMP signaling pathway.
Article in PLoS biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Mapping the regulatory architecture of circadian clock adaptation: A genome-wide eQTL analysis in Drosophila melanogaster.Heredity · 2026Article
- Differentially expressed microRNAs in brains of adult females may regulate the maternal block of diapause inCurrent research in insect science · 2024Article
- Decapentaplegic Acutely Defines the Connectivity of Central Pacemaker Neurons inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Shaping Waves of Bone Morphogenetic Protein Inhibition During Vascular Growth.Circulation research · 2020Article
- Modulators of hormonal response regulate temporal fate specification in the Drosophila brain.PLoS genetics · 2019Article
- Most sleep does not serve a vital function: Evidence fromScience advances · 2019Article
- Contribution of non-circadian neurons to the temporal organization of locomotor activity.Biology open · 2019Article
- Emerging roles for microRNA in the regulation of Drosophila circadian clock.BMC neuroscience · 2018Review
- Alternative cleavage of the bone morphogenetic protein (BMP), Gbb, produces ligands with distinct developmental functions and receptor preferences.The Journal of biological chemistry · 2017Article
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- Regulation of Dense-Core Granule Replenishment by Autocrine BMP Signalling in Drosophila Secondary Cells.PLoS genetics · 2016Article
- miR-124 Regulates Diverse Aspects of Rhythmic Behavior in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- miR-124 Regulates the Phase of Drosophila Circadian Locomotor Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Glial cell regulation of rhythmic behavior.Methods in enzymology · 2015Review
- Mmp1 processing of the PDF neuropeptide regulates circadian structural plasticity of pacemaker neurons.PLoS genetics · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Living organisms use biological clocks to maintain their internal temporal order and anticipate daily environmental changes. In Drosophila, circadian regulation of locomotor behavior is controlled by ∼150 neurons; among them, neurons expressing the PIGMENT DISPERSING FACTOR (PDF) set the period of locomotor behavior under free-running conditions. To date, it remains unclear how individual circadian clusters integrate their activity to assemble a distinctive behavioral output. Here we show that the BONE MORPHOGENETIC PROTEIN (BMP) signaling pathway plays a crucial role in setting the circadian period in PDF neurons in the adult brain. Acute deregulation of BMP signaling causes period lengthening through regulation of dClock transcription, providing evidence for a novel function of this pathway in the adult brain. We propose that coherence in the circadian network arises from integration in PDF neurons of both the pace of the cell-autonomous molecular clock and information derived from circadian-relevant neurons through release of BMP ligands.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.