ReviewInternational journal of biological sciences2013
The regulation of the autophagic network and its implications for human disease.
Review in International journal of biological sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- FOXO family and neurodegenerative diseases: Mechanisms of action and therapeutic potential.Redox biology · 2026Review
- Imbalanced TGFβ signalling and autophagy drive erythroid priming of hematopoietic stem cells in β-thalassemia.Nature communications · 2025Article
- Regulation of alveolar macrophage death in pulmonary fibrosis: a review.Apoptosis : an international journal on programmed cell death · 2023Review
- Phenol-Soluble Modulin α3 Stimulates Autophagy in HaCaT Keratinocytes.Biomedicines · 2023Article
- HSPB8 counteracts tumor activity of BRAF- and NRAS-mutant melanoma cells by modulation of RAS-prenylation and autophagy.Cell death & disease · 2022Article
- Targeting Heat Shock Proteins in Malignant Brain Tumors: From Basic Research to Clinical Trials.Cancers · 2022Review
- IL-36α and Lipopolysaccharide Cooperatively Induce Autophagy by Triggering Pro-Autophagic Biased Signaling.Biomedicines · 2021Article
- Review
- Retrobulbarly injecting nerve growth factor attenuates visual impairment in streptozotocin-induced diabetes rats.International ophthalmology · 2020Article
- Article
- Molecular mechanisms of methylglyoxal-induced aortic endothelial dysfunction in human vascular endothelial cells.Cell death & disease · 2020Article
- COPD-Related Modification to the Airway Epithelium Permits Intracellular Residence of NontypeableInternational journal of chronic obstructive pulmonary disease · 2020Article
- WX20120108, a novel IAP antagonist, induces tumor cell autophagy via activating ROS-FOXO pathway.Acta pharmacologica Sinica · 2019Article
- Article
- Apatinib Promotes Apoptosis of Pancreatic Cancer Cells through Downregulation of Hypoxia-Inducible Factor-1Oxidative medicine and cellular longevity · 2019Article
- Regulation of alveolar macrophage death in acute lung inflammation.Respiratory research · 2018Review
- Apatinib has anti-tumor effects and induces autophagy in colon cancer cells.Iranian journal of basic medical sciences · 2017Article
- Nuclear factor erythroid-2 related factor 2 (Nrf2)-mediated protein quality control in cardiomyocytes.Frontiers in bioscience (Landmark edition) · 2016Review
- Article
- The role of C/EBP-α expression in human liver and liver fibrosis and its relationship with autophagy.International journal of clinical and experimental pathology · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autophagy has attracted a lot of attention in recent years. More and more proteins and signaling pathways have been discovered that somehow feed into the autophagy regulatory pathways. Regulation of autophagy is complex and condition-specific, and in several diseases, autophagic fluxes are changed. Here, we review the most well-established concepts in this field as well as the reported signaling pathways or components which steer the autophagy machinery. Furthermore, we will highlight how autophagic fluxes are changed in various diseases either as cause for or as response to deal with an altered cellular homeostasis and how modulation of autophagy might be used as potential therapy for such diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.