Evidence map›Paper›PMID 24339269›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2014

Fluorescent probes based on nucleophilic substitution-cyclization for hydrogen sulfide detection and bioimaging.

Bo Peng, Wei Chen, Chunrong Liu, Ethan W Rosser, Armando Pacheco, Yu Zhao, Hector C Aguilar, Ming Xian

Abstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed.

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  4. Aboveground whole-plant live HRedox biology · 2026
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  5. Semi-Synthetic HACS medicinal chemistry letters · 2026
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  6. Thiophene Esters Are Not Selective for HACS chemical biology · 2025
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  7. Hydrogen Sulfide (HAntioxidants (Basel, Switzerland) · 2025
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  8. Sulfide regulation and catabolism in health and disease.Signal transduction and targeted therapy · 2025
    Review
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  12. Gas Delivery Relevant to Human Health using Porous Materials.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024
    Review
  13. Article
  14. Review
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  16. Article
  17. Review
  18. Enzyme-Triggered Chemodynamic Therapy via a Peptide-HAngewandte Chemie (International ed. in English) · 2023
    Article
  19. Article
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bo PengDepartment of Chemistry, Washington State University, Pullman, WA 99164 (USA), Fax: (+1) 509-335-8867.
Wei Chen
Chunrong Liu
Ethan W Rosser
Armando Pacheco
Yu Zhao
Hector C Aguilar
Ming Xian

Funding

Mechanisms of Nipah virus fusion and entryR01AI109022 · NIAID · WASHINGTON STATE UNIVERSITY · PI AGUILAR-CARRENO, HECTOR · 2014 to 2024
$4.3M
Chemical approaches for detecting S-nitrosothiolsR01GM088226 · NIGMS · WASHINGTON STATE UNIVERSITY · PI XIAN, MING · 2010 to 2014
$1.4M
NIAID NIH HHS R01 AI109022NIGMS NIH HHS R01 GM088226PHS HHS R01M088226
6 · The paper itself

Abstract

The design, synthesis, properties, and cell imaging applications of a series of 2-pyridyl disulfide based fluorescent probes (WSP1, WSP2, WSP3, WSP4 and WSP5) for hydrogen sulfide detection are reported. The strategy is based on the dual-nucleophilicity of hydrogen sulfide. A hydrogen sulfide mediated tandem nucleophilic substitution-cyclization reaction is used to release the fluorophores and turn on the fluorescence. The probes showed high sensitivity and selectivity for hydrogen sulfide over other reactive sulfur species, including cysteine and glutathione.

Indexed as

CyclizationCysteineDisulfidesFluorescent DyesGlutathioneHeLa CellsHumansHydrogen SulfideMicroscopy, FluorescenceCysteineDisulfidesFluorescent DyesGlutathioneHydrogen Sulfidecell imagingcyclizationfluorescencefluorescent probeshydrogen sulfide

Identifiers

PMID24339269
PMCPMC4049170

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.